Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Lung cancer in patients under age 40
Autore:
Skarin, AT; Herbst, RS; Leong, TL; Bailey, A; Sugarbaker, D;
Indirizzi:
Brigham & Womens Hosp, Dana Farber Canc Inst, Dept Adult Oncol, Boston, MA02115 USA Brigham & Womens Hosp Boston MA USA 02115 dult Oncol, Boston, MA02115 USA Harvard Univ, Sch Med, Boston, MA USA Harvard Univ Boston MA USAHarvard Univ, Sch Med, Boston, MA USA Brigham & Womens Hosp, Dana Farber Canc Inst, Dept Biostat, Boston, MA 02115 USA Brigham & Womens Hosp Boston MA USA 02115 t Biostat, Boston, MA 02115 USA Brigham & Womens Hosp, Dept Med, Boston, MA 02115 USA Brigham & Womens Hosp Boston MA USA 02115 Dept Med, Boston, MA 02115 USA Brigham & Womens Hosp, Dept Surg, Boston, MA 02115 USA Brigham & Womens Hosp Boston MA USA 02115 Dept Surg, Boston, MA 02115 USA
Titolo Testata:
LUNG CANCER
fascicolo: 3, volume: 32, anno: 2001,
pagine: 255 - 264
SICI:
0169-5002(200106)32:3<255:LCIPUA>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
YOUNG-ADULTS; BRONCHOGENIC-CARCINOMA; RISK-FACTORS; SMOKING;
Keywords:
lung cancer; lung cancer under age 40; adenocarcinoma; squamous cell carcinoma; small cell lung cancer; large cell lung cancer;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Skarin, AT Brigham & Womens Hosp, Dana Farber Canc Inst, Dept Adult Oncol,75 FrancisSt, Boston, MA 02115 USA Brigham & Womens Hosp 75 Francis St Boston MA USA 02115 115 USA
Citazione:
A.T. Skarin et al., "Lung cancer in patients under age 40", LUNG CANC, 32(3), 2001, pp. 255-264

Abstract

A retrospective review of patients < 40 years (n = 91) seen at the Dana-Farber Cancer Institute and Brigham and Women's Hospital from January I, 1983-January 1, 1993 was carried out. Of 91 patients, there were 43 men and 48 women with a median age of 36 years (range 28-39). Eighty percent of patients were cigarette smokers for a tnedian of 25 pack years (range 2-68). Ninety-one percent were symptomatic at presentation. The ECOG performance status (PS) was 0 or 1 in 83%.. At the time of diagnosis 15% had stage I/II, 17%stage IIIA, 22% stage IIIB and 45% stage IV disease. The most common histopathology was adenocarcinoma (46%). followed by small cell carcinoma (14%) squamous cell carcinoma (12%), large cell undifferentiated (8%) and other types (20%). The median survival for all 91 patients was 1 year with 2 and 5year survivals of 30% and 18% respectively. Five year survival was relatedto stage of disease: 60% for patients with stage I. 58%, for stage II. 36%for stage IIIA, 10% L for stags 111B, and 3% for stage IV disease. Factorsthat had no significant effect on overall survival included gender, histologic subtype. degree of differentiation, presence or absence of symptoms, and sites of metastases. Factors that adversely affected survival by univariate analysis included advanced stage of disease, poor PS. duration of symptoms for more than 3 months, and 5% or greater body weight loss. By multivariate analysis only stage (P < 0.001) and weight loss (P = 0.02) affected survival. This data plus results of other published studies show that young patients under age 40 with lung cancer. compared to the more common older patients, have an increased percentage of women, have a longer duration of symptoms, more often have adenocarcinoma with lower frequency of squamous cell carcinoma and sometimes small cell carcinoma, and more often present withadvanced disease. Despite these differences, overall patient survival remains poor and is similar to that of older patients. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/04/20 alle ore 22:22:42