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Titolo:
Treatment of mastocytosis: pharmacologic basis and current concepts
Autore:
Marone, G; Spadaro, G; Granata, F; Triggiani, M;
Indirizzi:
Univ Naples Federico II, Fac Med, Div Clin Immunol & Allergol, I-80131 Naples, Italy Univ Naples Federico II Naples Italy I-80131 rgol, I-80131 Naples, Italy
Titolo Testata:
LEUKEMIA RESEARCH
fascicolo: 7, volume: 25, anno: 2001,
pagine: 583 - 594
SICI:
0145-2126(200107)25:7<583:TOMPBA>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN MAST-CELLS; EPSILON-RI+ CELLS; PROTEIN-KINASE-C; ORAL DISODIUM-CROMOGLYCATE; MEDIATED HISTAMINE-RELEASE; ACTIVATES HUMAN BASOPHILS; SYSTEMIC MASTOCYTOSIS; URTICARIA PIGMENTOSA; ARACHIDONIC-ACID; CYCLOSPORINE-A;
Keywords:
basophils; histamine; leukotrienes; mast cells; mastocytosis; therapy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
107
Recensione:
Indirizzi per estratti:
Indirizzo: Marone, G Univ Naples Federico II, Fac Med, Div Clin Immunol & Allergol, Via S Pansini 5, I-80131 Naples, Italy Univ Naples Federico II Via S Pansini5 Naples Italy I-80131 ly
Citazione:
G. Marone et al., "Treatment of mastocytosis: pharmacologic basis and current concepts", LEUK RES, 25(7), 2001, pp. 583-594

Abstract

Mastocytosis is a rare, heterogeneous disorder characterized by a marked increase in mast cell density in various tissues. Mast cells from different human tissues are heterogeneous. So far, there is no cure for systemic mastocytosis. Conventional therapy is based on agents that antagonize mediatorsreleased from mast cells, drugs that inhibit the release of mediators and agents that modulate mast cell proliferation. This pharmacologic approach is satisfactory in the majority of patients with indolent mastocytosis. At the beginning of the new millennium, the therapy of severe forms of aggressive mastocytosis remains a challenge for students of this intriguing disorder. (C) 2001 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 03:09:22