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Titolo:
Gastro cystoplasty and chronic renal failure: An acid-base metabolism study
Autore:
de Freitas, LG; Carnevale, J; Leao, JQS; Schor, N; Ortiz, V;
Indirizzi:
Univ Fed Sao Paulo, Escola Paulista Med, Dept Surg & Nephrol, BR-04024002 Sao Paulo, Brazil Univ Fed Sao Paulo Sao Paulo Brazil BR-04024002 BC4002 Sao Paulo, Brazil
Titolo Testata:
JOURNAL OF UROLOGY
fascicolo: 1, volume: 166, anno: 2001,
pagine: 251 - 254
SICI:
0022-5347(200107)166:1<251:GCACRF>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
URINARY-DIVERSION; GASTROCYSTOPLASTY; BLADDER; RECONSTRUCTION;
Keywords:
kidney; bladder; urinary diversion; rats, Wistar; acidosis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: de Freitas, LG Univ Fed Sao Paulo, Escola Paulista Med, Dept Surg & Nephrol, Rua Botucatu862, BR-04024002 Sao Paulo, Brazil Univ Fed Sao Paulo Rua Botucatu 862 Sao Paulo Brazil BR-04024002 BC
Citazione:
L.G. de Freitas et al., "Gastro cystoplasty and chronic renal failure: An acid-base metabolism study", J UROL, 166(1), 2001, pp. 251-254

Abstract

Purpose: To verify in an experimental model whether gastrocystoplasty may protect patients with chronic renal failure from acid loading associated acidosis a wedge-shaped portion of the middle stomach was used to improve bladder capacity in animals with chronic renal failure. Materials and Methods: An experimental model was used to study 112 adult female Wistar rats (EPM-1) weighing between 156 and 259 gm. The animals wererandomly assigned to groups, including 41 controls, 24 undergoing five-sixths nephrectomy to create chronic renal failure, 26 undergoing gastrocystoplasty and 21 undergoing gastrocystoplasty and five-sixths nephrectomy to create renal failure. To provide an acid overload a 5% NH4Cl diet was administered to a subgroup of each group. Two months after surgery 24-hour urine was collected, and volume and pH were measured as well as the amount of bicarbonate, ammonium, titratable acidity and chloride. The animals were then exsanguinated through an abdominal aorta puncture. The blood was used for blood gas analysis and to measure sodium, potassium, chloride, ionized calcium and creatinine. Results: When undergoing an acid overload, the animals with gastrocystoplasty had no acidosis since acid radicals were eliminating in the urine as NH4Cl. When given the same acid overload, metabolic acidosis developed in theanimals with gastrocystoplasty and chronic renal failure. Conclusions: Gastrocystoplasty protected healthy rats from acidosis when they were given an acid overload but failed to protect the rats with chronicrenal failure under the same conditions.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 10:18:29