Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Prolonged inhibition of presynaptic catecholamine synthesis with alpha-methyl-para-tyrosine attenuates the circadian rhythm of human TSH secretion
Autore:
Zimmermann, RC; Krahn, LE; Klee, GG; Ditkoff, EC; Ory, SJ; Sauer, MV;
Indirizzi:
Columbia Univ, Dept Obstet & Gynecol, Div Reprod Endocrinol, New York, NY 10032 USA Columbia Univ New York NY USA 10032 od Endocrinol, New York, NY 10032 USA Mayo Clin & Mayo Fdn, Dept Lab Med & Pathol, Sleep Disorders Ctr, Rochester, MN 55905 USA Mayo Clin & Mayo Fdn Rochester MN USA 55905 Ctr, Rochester, MN 55905 USA Mayo Clin & Mayo Fdn, Div Adult Psychiat, Rochester, MN 55905 USA Mayo Clin & Mayo Fdn Rochester MN USA 55905 hiat, Rochester, MN 55905 USA
Titolo Testata:
JOURNAL OF THE SOCIETY FOR GYNECOLOGIC INVESTIGATION
fascicolo: 3, volume: 8, anno: 2001,
pagine: 174 - 178
SICI:
1071-5576(200105/06)8:3<174:PIOPCS>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
THYROTROPIN SECRETION; DOPAMINERGIC CONTROL; MENSTRUAL-CYCLE; NORMAL WOMEN; RELEASE; TRYPTOPHAN; RAT; PROLACTIN; INFUSION;
Keywords:
AMPT; circadian rhythm; melatonin; norepinephrine; prolactin; thyrotropin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Zimmermann, RC Columbia Univ, Dept Obstet & Gynecol, Div Reprod Endocrinol, 630 W 168th St, New York, NY 10032 USA Columbia Univ 630 W 168th St New York NY USA 10032 0032 USA
Citazione:
R.C. Zimmermann et al., "Prolonged inhibition of presynaptic catecholamine synthesis with alpha-methyl-para-tyrosine attenuates the circadian rhythm of human TSH secretion", J SOC GYN I, 8(3), 2001, pp. 174-178

Abstract

OBJECTIVE: Originating from the pituitary gland, TSH secretion is regulated predominantly by thryoid-relesing hormone (TRH) neurons located in the hypothalamus. Norepinephrine and dopamine have important effects in modulation of TSH secretion. An inhibitor of catecholamine synthesis, alpha -mehtyl-para-tyrosine (AMPT) has been used in several studies of the regulation of human TSH secretion, Tile short-term effects (<8 hours) of low doses of AMPT include stimulation of pituitary TSH secretion by selective lowering of brain dopamine levels. After prolonged administration of AMPT (> 24 hours), theoretically both dopamine and norepinephrine levels are lowered significantly in the brain, although this has not been reported previously. METHODS:Nine subjects (five women and four men) received a total of five 1-g dosesof AMPT or five 50-mg doses of promethazine (active placebo) over 28 hoursin a randomized, double-blind, placebo-controlled crossover design in which tile active and control tests were separated by 4- 6 weeks. Blood sampleswere obtained over 24 hours (18 time points) on dy 2 of each condition. RESULTS: Changes in prolactin secretion and 6-hydromelatonin sulfate excretion indirectly showed the effects of AMPT on dopamine and norepinephrine. Thetypical circadian rhythm of TSH secretion was blunted by AMPT throughtout the night; at ten time points, the difference between the two groups was statistically significant (P <.01). The long-term effects of repeated doses of AMPT were inhibition of TSH secretion and significant attenuation of the ciadian rhythm of TSH. Additionally, AMPT induced low norepinephrine levels, which counteracted the stimulatory effect of low dopamine levels on TSH. CONCLUSION: Through its inhibitory effect on TRH, norepinephrine appeared to be involved in the regulation of TSH. (J Soc Gynecol Investig 2001;8:174-8) Copyright <(c)> 2001 by the Society for Gynecologic Investigation. Gynecologic Investigation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 10:14:15