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Titolo:
Circulatory responses to acute asphyxia are not affected by the glutamate antagonist lubeluzole in fetal sheep near term
Autore:
Berger, R; Garnier, Y; Lobbert, T; Pfeiffer, D; Jensen, A;
Indirizzi:
Ruhr Univ Bochum, Dept Obstet & Gynecol, D-4630 Bochum, Germany Ruhr Univ Bochum Bochum Germany D-4630 & Gynecol, D-4630 Bochum, Germany
Titolo Testata:
JOURNAL OF THE SOCIETY FOR GYNECOLOGIC INVESTIGATION
fascicolo: 3, volume: 8, anno: 2001,
pagine: 143 - 148
SICI:
1071-5576(200105/06)8:3<143:CRTAAA>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
BLOOD-FLOW DISTRIBUTION; ISCHEMIC STROKE; BRAIN-DAMAGE; DELIVERY; NEURONS; SAFETY; RATS;
Keywords:
circulation; fetal sheep; intrauterine asphyxia; lubeluzole; neuroprotection;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Berger, R Ruhr Univ Bochum, Frauenklin, Knappschaftskrankenhaus, Schornau 23-25, D-44892 Bochum, Germany Ruhr Univ Bochum Schornau 23-25 Bochum Germany D-44892 Germany
Citazione:
R. Berger et al., "Circulatory responses to acute asphyxia are not affected by the glutamate antagonist lubeluzole in fetal sheep near term", J SOC GYN I, 8(3), 2001, pp. 143-148

Abstract

OBJECTIVE: Asphyxia is one of the main causes of perinatal brain damage that can result in psychomotor deficits during later development. Recently lubeluzole, a new glutamate antagonist, was shown to improve clinical outcomeconsiderably without any safety concerns in adults who had acute ischemic stroke. However, our preliminary experiments showed transient alterations in heart rate as well as arterial hypertension after intravenous applicationof this compound in fetal sheep. The dim of the present study was to examine in detail whether lubeluzole affects circulatory responses to acute asphyxia in fetal sheep near term. METHODS: Eleven fetal sheep were chronically instrumented at a mean gestational age of 133 +/- 2 days (term is at 147 days). The fetuses in the studygroup (n = 6) received three bolus injections of lubeluzole at 30-minute intervals (3 X 0.11 mg/kg estimated body weight), and five controls receivedsolvent. Organ blood flows and physiologic variables were measured before,during, and after arrest of uterine blood flow for 2 minutes (ie, at 0, 1,2, 3, 4, and 30 minutes). RESULTS: Before asphyxia, distribution of combined ventricular output and physiologic variables in fetuses from the control group were in the normal range for chronically prepared fetal sheep near term. During acute asphyxiathere was a redistribution of cardiac output toward the central organs accompanied by pronounced bradycardia and progressive increase in arterial blood pressure. There were nearly no differences between groups in the time course of physiologic and cardiovascular variables measured before, during, and after acute intrauterine asphyxia. CONCLUSION: Lubeluzole did not affect circulatory responses to acute asphyxia in fetal sheep near term. Copyright (C) 2001 by the Society for Gynecologic Investigation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 21:23:28