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Titolo:
Endotoxemia severely affects circulation during normoxia and asphyxia in immature fetal sheep
Autore:
Garnier, Y; Coumans, A; Berger, R; Jensen, A; Hasaart, THM;
Indirizzi:
Ruhr Univ Bochum, Dept Obstet & Gynecol, D-4630 Bochum, Germany Ruhr Univ Bochum Bochum Germany D-4630 & Gynecol, D-4630 Bochum, Germany Univ Maastricht, Dept Obstet & Gynecol, Maastricht, Netherlands Univ Maastricht Maastricht Netherlands Gynecol, Maastricht, Netherlands
Titolo Testata:
JOURNAL OF THE SOCIETY FOR GYNECOLOGIC INVESTIGATION
fascicolo: 3, volume: 8, anno: 2001,
pagine: 134 - 142
SICI:
1071-5576(200105/06)8:3<134:ESACDN>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
BLOOD-FLOW DISTRIBUTION; OXYGEN DELIVERY; HEMORRHAGE; RESPONSES; PLACENTA; DAMAGE; LAMB; CORD;
Keywords:
endotoxin; lipopolysaccharides; intrauterine infection; circulation; cerebral blood now; cerebral ischemia; perinatal brain damage; fetal sheep; asphyxia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Berger, R Ruhr Univ Bochum, Frauenklin, Knappschaftskrankenhaus, Schornau 23-25, D-44892 Bochum, Germany Ruhr Univ Bochum Schornau 23-25 Bochum Germany D-44892 Germany
Citazione:
Y. Garnier et al., "Endotoxemia severely affects circulation during normoxia and asphyxia in immature fetal sheep", J SOC GYN I, 8(3), 2001, pp. 134-142

Abstract

OBJECTIVE: The purpose of the present study was to determine whether endotoxins (lipopolysaccharides, LPS) affect the fetal cardiovascular system in a may likely to cause brain damage. METHODS: Thirteen fetal sheep were chronically instrumented at a mean gestational age of 107 +/- 1 days. After control measurements of organ flow (microscphere method), blood gases, and acid base balance were obtained, seven of 13 fetuses received LPS (53 +/- 3 mug/kg fetal weight) intravenously. Sixty minutes later, asphyxia was inducedby occlusion of the maternal aorta for 2 minutes. Measurements of organ blood flows were made at -60, -1, +2, +4, +30, and +60 minutes. RESULTS: Unlike in the control group, after LPS infusion there was a significant decrease in arterial oxygen saturation (-46%; P < .001) and pH (P < .001). In LPS-treated fetuses the portion of combined ventricular output directed to the placenta decreased significantly (-76%; P < .001), whereas output to the fetal body (+60%; P < .001), heart (+167%; P < .05), and adrenals (+229%; P <.01) increased. Furthermore, during asphyxia circulatory centralization was impaired considerably in LPS-treated fetuses, and there was a clear evidence of circulatory decentralization. This decentralization caused a severe decrease in cerebral oxygen delivery by 70%. Within 30 minutes after induction of asphyxia five of seven LPS-treated fetuses died, whereas all controlfetuses recovered completely. CONCLUSIONS: Endotoxemia severely impaired fetal cardiovascular control during normoxia and asphyxia, resulting in a considerable decrease in cerebral oxygen delivery. Theses effects might have important effects in the development of fetal brain damage associated with intrauterine infection. (J Soc Gynecol Investig 2001; 8:134-42) Copyright (C) 2001 by the Society for Gynecologic Investigation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 20:47:48