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Titolo:
Post-prandial remnant lipids impair arterial compliance
Autore:
Nestel, PJ; Shige, H; Pomeroy, S; Cehun, M; Chin-Dusting, J;
Indirizzi:
Baker Med Res Inst, Melbourne, Vic, Australia Baker Med Res Inst Melbourne Vic Australia st, Melbourne, Vic, Australia
Titolo Testata:
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
fascicolo: 7, volume: 37, anno: 2001,
pagine: 1929 - 1935
SICI:
0735-1097(20010601)37:7<1929:PRLIAC>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTERMEDIATE-DENSITY LIPOPROTEINS; CORONARY HEART-DISEASE; HIGH-FAT MEAL; ENDOTHELIAL FUNCTION; HYPERCHOLESTEROLEMIC HUMANS; RISK; MEN; HYPERTRIGLYCERIDEMIA; VASODILATION; CHOLESTEROL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Nestel, PJ Baker Med Res Inst, POB 6492,St Kilda Rd Cent, Melbourne, Vic, Australia Baker Med Res Inst POB 6492,St Kilda Rd Cent Melbourne Vic Australia
Citazione:
P.J. Nestel et al., "Post-prandial remnant lipids impair arterial compliance", J AM COL C, 37(7), 2001, pp. 1929-1935

Abstract

OBJECTIVES We sought to examine the effects of plasma lipids, especially in remnants after a fat meal, on systemic arterial compliance (SAC), a newlyrecognized cardiovascular risk factor. BACKGROUND Post-prandial remnants correlate with coronary heart disease events through mechanisms that may include vascular dysfunction, although theeffect on SAC has not been studied. METHODS Systemic arterial compliance was measured non-invasively over 6 h after a fat meal in 16 subjects with varying plasma triglyceride levels. Changes were related to rises in plasma lipids and remnant lipids. Systemic arterial compliance was measured in 20 subjects after a control low-fat meal. RESULTS The fat meal induced increments in plasma triglyceride and remnantcholesterol and triglyceride (respectively +54%, 50% and 290% at 3 h, analysis of variance <0.001). Systemic arterial compliance fell at 3 h and 6 h by 25% and 27% (analysis of variance <0.001). Baseline SAC correlated significantly with all lipid concentrations at 0, 3 h and 6 h, but only with triglyceride on stepwise regression analysis. The SAC response to the low-fat meal was very small and not significant. CONCLUSIONS This is the first demonstration of SAC becoming impaired aftera fat meal. Remnant lipids and plasma total triglyceride appeared to contribute to the fall in SAG. (J Am Coll Cardiol 2001;37:1929-35) (C) 2001 by the American College of Cardiology.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 10:35:15