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Titolo:
Intravenous atrial natriuretic peptide prevents left ventricular remodeling in patients with first anterior acute myocardial infarction
Autore:
Hayashi, M; Tsutamoto, T; Wada, A; Maeda, K; Mabuchi, N; Tsutsui, T; Horie, H; Ohnishi, M; Kinoshita, M;
Indirizzi:
Shiga Univ Med Sci, Dept Internal Med 1, Otsu, Shiga 5202192, Japan Shiga Univ Med Sci Otsu Shiga Japan 5202192 1, Otsu, Shiga 5202192, Japan
Titolo Testata:
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
fascicolo: 7, volume: 37, anno: 2001,
pagine: 1820 - 1826
SICI:
0735-1097(20010601)37:7<1820:IANPPL>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
CONGESTIVE-HEART-FAILURE; ANGIOTENSIN-CONVERTING ENZYME; CARDIAC FIBROBLASTS; RECEPTOR BLOCKADE; ALDOSTERONE; ENDOTHELIN-1; INHIBITION; HYPERTROPHY; SURVIVAL; FIBROSIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Tsutamoto, T Shiga Univ Med Sci, Dept Internal Med 1, Otsu, Shiga 5202192,Japan Shiga Univ Med Sci Otsu Shiga Japan 5202192 a 5202192, Japan
Citazione:
M. Hayashi et al., "Intravenous atrial natriuretic peptide prevents left ventricular remodeling in patients with first anterior acute myocardial infarction", J AM COL C, 37(7), 2001, pp. 1820-1826

Abstract

OBJECTIVES The study evaluates the effect of atrial natriuretic peptide (ANP) compared with nitroglycerin (GTN) on left ventricular (LV) remodeling after first anterior acute myocardial infarction (AMI). BACKGROUND Compared with GTN, ANP suppresses the renin-angiotensin-aldosterone system and endothelin-1 (ET-1), which stimulate LV remodeling. METHODS Sixty patients with a first anterior AMI were randomly divided into the ANP (n = 30) or GTN (n = 30) groups after direct percutaneous transluminal coronary angioplasty. We evaluated LV ejection fraction (LVEF), end-diastolic volume index (LVEDVI) and endsystolic volume index (LVESVI) at theacute phase and after one month. We also measured neurohumoral factors during study drug infusion. RESULTS There nas no difference in the baseline characteristics or LVEF (46.9 +/- 1.0 vs. 46.8 +/- 1.3%) between the two groups. Although there was no difference in hemodynamics during the infusion periods, the LVEF tvas significantly improved after one month compared with the baseline value in both groups, but it was improved more in the ANP group than in the GTN group (54.6 +/- 1.1%, 50.8 +/- 1.3%, p < 0.05). Left ventricular enlargement was prevented in the ANP group (LVEDVI, 85.8 +/- 3.1 ml/m(2) to 87.3 +/- 2.7 ml/m(2); p = ns, LVESVI, 45.6 +/- 1.8 ml/m(2) to 41.0 +/- 2.1 ml/m(2), p < 0.05) but not in the GTN group (LVEDVI, 86.2 +/- 4.1 to 100.2 +/- 3.7, p < 0.01; LVESVI, 46.3 +/- 2.8 ml/m(2) to 51.1 +/- 3.0 ml/m(2), p = ns). During the infusion, ANP suppressed plasma levels of aldosterone, angiotensin II andET-1 compared with GTN. CONCLUSIONS These findings indicate that in patients with a first anteriorAMI, an ANP infusion can prevent LV remodeling better than can GTN, and effectively suppresses aldosterone, angiotensin II and ET-1. (J Am Coll Cardiol 2001;37:1820-6) (C) 2001 by the American College of Cardiology.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/09/20 alle ore 06:51:01