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Titolo:
Increased cerebral response during a divided attention task following sleep deprivation
Autore:
Drummond, SPA; Gillin, JC; Brown, GG;
Indirizzi:
Univ Calif San Diego, San Diego Vet Affairs Med Ctr, Dept Psychiat, San Diego, CA 92161 USA Univ Calif San Diego San Diego CA USA 92161 hiat, San Diego, CA 92161 USA
Titolo Testata:
JOURNAL OF SLEEP RESEARCH
fascicolo: 2, volume: 10, anno: 2001,
pagine: 85 - 92
SICI:
0962-1105(200106)10:2<85:ICRDAD>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
FUNCTIONAL MRI; BRAIN SYSTEMS; ACTIVATION; MEMORY; FMRI; RETRIEVAL; DISEASE; CORTEX; HUMANS; PET;
Keywords:
divided attention; FMRI; parietal lobes; prefrontal cortex; sleep deprivation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Drummond, SPA Univ Calif San Diego, San Diego Vet Affairs Med Ctr, Dept Psychiat, 9116 A,3350 La Jolla Village Dr, San Diego, CA 92161 USA Univ CalifSan Diego 9116 A,3350 La Jolla Village Dr San Diego CA USA 92161
Citazione:
S.P.A. Drummond et al., "Increased cerebral response during a divided attention task following sleep deprivation", J SLEEP RES, 10(2), 2001, pp. 85-92

Abstract

We recently reported that the brain showed greater responsiveness to some cognitive demands following total sleep deprivation (TSD). Specifically, verbal learning led to increased cerebral activation following TSD while arithmetic resulted in decreased activation. Here we report data from a dividedattention task that combined verbal learning and arithmetic. Thirteen normal control subjects performed the task while undergoing functional magneticresonance imaging (FMRI) scans after a normal night of sleep and following35 h TSD. Behaviourally. subjects showed only modest impairments followingTSD. With respect to cerebral activation, the results showed (a) increasedactivation in the prefrontal cortex and parietal lobes, particularly in the right hemisphere, following TSD, (b) activation in left inferior frontal gyrus correlated with increased subjective sleepiness after TSD, and (c) activation in bilateral parietal lobes correlated with the extent of intact memory performance after TSD. Many of the brain regions showing a greater response after TSD compared with normal sleep are thought to be involved in control of attention. These data imply that the divided attention task required more attentional resources (specifically, performance monitoring and sustained attention) following TSD than after normal sleep. Other neuroimaging results may relate to the verbal learning and/or arithmetic demands of the task. This is the first study to examine divided attention performance after TSD with neuroimaging and supports our previous suggestion that the brain may be mon plastic during cognitive performance following TSD than previously thought.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 06:42:08