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Titolo:
Polymorphism of DNA/multi-cationic lipid complexes driven by temperature and salts
Autore:
Raspaud, E; Pitard, B; Durand, D; Aguerre-Chariol, O; Pelta, J; Byk, G; Scherman, D; Livolant, F;
Indirizzi:
Univ Paris Sud, Phys Solides Lab, CNRS, UMR 8502, F-91405 Orsay, France Univ Paris Sud Orsay France F-91405 NRS, UMR 8502, F-91405 Orsay, France Ctr Rech Vitry Alfortville, CNRS, UMR 7001, ENSCP Aventis, F-94403 Vitry, France Ctr Rech Vitry Alfortville Vitry France F-94403 s, F-94403 Vitry, France Univ Paris Sud, LURE, CNRS, UMR 130, F-91898 Orsay, France Univ Paris SudOrsay France F-91898 CNRS, UMR 130, F-91898 Orsay, France Bar Ilan Univ, Dept Chem, Lab Peptidomimet & Genet Chem, IL-52900 Ramat Gan, Israel Bar Ilan Univ Ramat Gan Israel IL-52900 Chem, IL-52900 Ramat Gan, Israel Rhodia, F-93309 Aubervilliers, France Rhodia Aubervilliers France F-93309 hodia, F-93309 Aubervilliers, France
Titolo Testata:
JOURNAL OF PHYSICAL CHEMISTRY B
fascicolo: 22, volume: 105, anno: 2001,
pagine: 5291 - 5297
SICI:
1520-6106(20010607)105:22<5291:PODLCD>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
ELECTRON-MICROSCOPY; CATANIONIC VESICLES; DNA; PHASE; LIPOSOMES; DELIVERY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Livolant, F Univ Paris Sud, Phys Solides Lab, CNRS, UMR 8502, F-91405 Orsay, France Univ Paris Sud Orsay France F-91405 2, F-91405 Orsay, France
Citazione:
E. Raspaud et al., "Polymorphism of DNA/multi-cationic lipid complexes driven by temperature and salts", J PHYS CH B, 105(22), 2001, pp. 5291-5297

Abstract

The structural polymorphism of DNA/lipopolyamine (multi-cationic lipid) complexes has been studied by X-ray diffraction and cryo-electron microscopy. Monovalent salt and temperature effects have been analyzed. Depending on the treatment applied to the lipidic solution prior to DNA addition, two types of structure can be obtained for identical final conditions: a classicallamellar structure and a more complex structure, The latter was shown to appear when the lipidic solution prepared in high salt condition is vortexedand quenched below the hydrocarbon chain melting temperature, before addition to the DNA solution. It corresponds to some small facetted vesicles. Similar behavior is observed for the poly(styrene-sulfonate)/lipid system.

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Documento generato il 11/07/20 alle ore 21:03:27