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Titolo:
Thermodynamic properties and swelling behavior of glycolipid monolayers atinterfaces
Autore:
Schneider, MF; Mathe, G; Tanaka, M; Gege, C; Schmidt, RR;
Indirizzi:
Tech Univ Munich, Lehrstuhl Biophys E22, D-85748 Garching, Germany Tech Univ Munich Garching Germany D-85748 E22, D-85748 Garching, Germany Univ Konstanz, Fachbereich Chem, D-78457 Constance, Germany Univ KonstanzConstance Germany D-78457 Chem, D-78457 Constance, Germany
Titolo Testata:
JOURNAL OF PHYSICAL CHEMISTRY B
fascicolo: 22, volume: 105, anno: 2001,
pagine: 5178 - 5185
SICI:
1520-6106(20010607)105:22<5178:TPASBO>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
CARBOHYDRATE-CARBOHYDRATE RECOGNITION; ATTACHED POLY(ETHYLENE GLYCOL); AIR-WATER-INTERFACE; PHOSPHOLIPID MONOLAYERS; INTERACTION FORCES; CELL RECOGNITION; LIPID MONOLAYERS; BILAYERS; SURFACES; ADHESION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Citazioni:
59
Recensione:
Indirizzi per estratti:
Indirizzo: Tanaka, M Tech Univ Munich, Lehrstuhl Biophys E22, James Franck Str, D-85748 Garching, Germany Tech Univ Munich James Franck Str Garching Germany D-85748 many
Citazione:
M.F. Schneider et al., "Thermodynamic properties and swelling behavior of glycolipid monolayers atinterfaces", J PHYS CH B, 105(22), 2001, pp. 5178-5185

Abstract

Synthetic glycolipids with lactose headgroups (N = 1, 2, and 3) were synthesized, and their thermodynamic properties were systematically studied by Langmuir isotherms using a film balance. The molar transition entropy and the molar latent heat were calculated by applying the Clausius-Clapeyron equation. It has been demonstrated that the phase behavior of the glycolipid monolayers is comparable to that of ordinary phospholipids, despite the lowerdegree of cooperativity between the larger headgroups. The glycolipid monolayer was transferred onto a solid surface by Langmuir-Blodgett deposition,and the swelling behavior was investigated by ellipsometry. The surface grafting density was precisely controlled, and the water disjoining pressure inside the lactose layer was quantitatively measured. The measured swellingcurves were analyzed in terms of the theoretical descriptions for the grafted polymer "brushes". For the lipids with lactose units of N = 2 and 3, the disjoining pressure-thickness relation could fit very well to these theoretical approaches, even though the statistical limit N much greater than 1 is hardly fulfilled. The results suggest entropic effects of the headgroupson the interaction between the neighboring molecules. On the other hand, the theoretical description of the swelling behavior of the lipids with one lactose unit failed due to the "rodlike" structure of lactose. The unique properties of these glycolipids at interfaces, such as (i) the phase behavior comparable to that of ordinary phospholipids and (ii) the "polymer-like" swelling behavior, play very important roles in biological systems. Mimicking the complex interactions between oligosaccharide headgroups in the plasma membranes, the synthetic glycolipids designed in this study are quite realistic models for the glycocalix.

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Documento generato il 05/04/20 alle ore 09:39:37