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Titolo:
Behavioral taste similarities and differences among monosodium L-glutamateand glutamate receptor agonists in C57BL mice
Autore:
Nakashima, K; Katsukawa, H; Sasamoto, K; Ninomiya, Y;
Indirizzi:
Asahi Univ, Sch Dent, Dept Chem, Hozumi, Gifu 5010296, Japan Asahi Univ Hozumi Gifu Japan 5010296 pt Chem, Hozumi, Gifu 5010296, Japan Asahi Univ, Sch Dent, Dept Oral Physiol, Hozumi, Gifu 5010296, Japan AsahiUniv Hozumi Gifu Japan 5010296 Physiol, Hozumi, Gifu 5010296, Japan Kyushu Univ, Grad Sch Dent Sci, Sect Oral Neurosci, Higashi Ku, Fukuoka 8128582, Japan Kyushu Univ Fukuoka Japan 8128582 ci, Higashi Ku, Fukuoka 8128582, Japan
Titolo Testata:
JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY
fascicolo: 2, volume: 47, anno: 2001,
pagine: 161 - 166
SICI:
0301-4800(200104)47:2<161:BTSADA>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEURAL RESPONSES; UMAMI SUBSTANCES; AMINO-ACIDS; RAT; DISCRIMINATION; CELLS; NMDA;
Keywords:
monosodium L-glutamate; L(+)-2-amino-4-phosphonobutyrate; N-methyl-D-aspartate; conditioned taste aversion paradigm; mice;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Nakashima, K Asahi Univ, Sch Dent, Dept Chem, 1851-1 Hozumi, Hozumi, Gifu 5010296, Japan Asahi Univ 1851-1 Hozumi Hozumi Gifu Japan 5010296 296, Japan
Citazione:
K. Nakashima et al., "Behavioral taste similarities and differences among monosodium L-glutamateand glutamate receptor agonists in C57BL mice", J NUTR SC V, 47(2), 2001, pp. 161-166

Abstract

Monosodium L-glutamate (MSG) and 5'-ribonucleotides elicit umami taste in humans and probably in some species of animals, Previous studies suggest that taste-mGluR4 and NMDA receptor may be involved in taste transduction forumami, but behavioral responses in rats do not support the involvement of NMDA receptor. In the present study, behavioral similarities and differences among MSG, mGluR4 agonist L(+)-2-amino-4-phosphonobutyrate (L-AP4), and NMDA receptor agonist N-methyl-D-aspartate (NMDA) were compared in C57BL mice by using a conditioned taste aversion paradigm. Mice conditioned to avoideither MSG or 10 mM L-AP4 appeared to avoid MSG, disodium 5'-inosinate (IMP), a mixture of MSG and IMP, and L-AP4, but not NMDA. Aversive conditioning to either sucrose or NMDA was generalized only to a mixture of MSG+IMP orNaCl. However, aversive conditioning to L-AP4 at 1 mM was generalized to NMDA and the umami substances. Licit rates for L-AP4 increased by mixing with (RS)-alpha -cycloprophy-4-phosphonophenylglycine (mGluR4 antagonist) whenanimals were conditioned to avoid MSG or L-AP4. Lick rates for NMDA also either decreased or increased by mixing with glycine (NMDA receptor coagonist) or D(-)-2-amino-5-phosphonopentanoic acid (NMDA receptor antagonist) when animals were conditioned to avoid L-AP4 or NMDA. In sucrose-conditioned mice, gurmarin (a sweet inhibiting peptide) suppressed the avoidance of sucrose and a mixture of MSG and IMP, but not L-AP4 and NMDA. The results suggest the possibility that to C57BL mice MSG may taste similar to L-AP4 but different from NMDA, although both types of glutamate receptors as well as gurmarin-sensitive sweet receptor may be involved in perception of umami taste.

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Documento generato il 29/03/20 alle ore 10:37:12