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Titolo:
Tributyrin, a stable and rapidly absorbed prodrug of butyric acid, enhances antiproliferative effects of dihydroxycholecalciferol in human colon cancer cells
Autore:
Gaschott, T; Steinhilber, D; Milovic, V; Stein, J;
Indirizzi:
Univ Frankfurt, Dept Med 2, D-6000 Frankfurt, Germany Univ Frankfurt Frankfurt Germany D-6000 Med 2, D-6000 Frankfurt, Germany Univ Frankfurt, Inst Pharmaceut Chem, D-6000 Frankfurt, Germany Univ Frankfurt Frankfurt Germany D-6000 Chem, D-6000 Frankfurt, Germany
Titolo Testata:
JOURNAL OF NUTRITION
fascicolo: 6, volume: 131, anno: 2001,
pagine: 1839 - 1843
SICI:
0022-3166(200106)131:6<1839:TASARA>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
APICAL MEMBRANE-VESICLES; VITAMIN-D-RECEPTOR; RAT DISTAL COLON; SODIUM-BUTYRATE; CACO-2 CELLS; IN-VITRO; DIFFERENTIATING AGENTS; CARCINOMA CELLS; LEUKEMIA-CELLS; GROWTH ARREST;
Keywords:
colon cancer; dihydroxycholecalciferol; tributyrin; vitamin D receptor;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Stein, J Univ Frankfurt, Dept Med 2, D-6000 Frankfurt, Germany Univ Frankfurt Frankfurt Germany D-6000 6000 Frankfurt, Germany
Citazione:
T. Gaschott et al., "Tributyrin, a stable and rapidly absorbed prodrug of butyric acid, enhances antiproliferative effects of dihydroxycholecalciferol in human colon cancer cells", J NUTR, 131(6), 2001, pp. 1839-1843

Abstract

Tributyrin, a prodrug of natural butyrate, has been evaluated with an aim to overcome pharmacokinetic drawbacks of natural butyrate as a drug, i.e., its rapid metabolization and inability to achieve pharmacologic concentrations in neoplastic cells. We studied the effects of tributyrin on growth, differentiation and vitamin D receptor expression in Caco-2 cells, a human colon cancer cell line. Tributyrin was more potent in inhibiting growth and inducing cell differentiation than natural butyrate. The effect was further enhanced after addition of physiologic concentrations of dihydroxycholecalciferol [(OH)(2)D-3]. The synergistic effect of tributyrin and (OH)(2)D-3 inCaco-2 cells was due to tributyrin-induced overexpression of the vitamin Dreceptor, as measured by reverse transcriptase-polymerase chain reaction. Treatment with tributyrin increased binding of (OH)(2)D-3 to its receptor 1.5-fold, without any change in receptor affinity. We conclude that tributyrin may, at least in part, exert its growth-reducing and differentiation-inducing effect in Caco-2 cells by an upregulation of the vitamin D receptor, this may provide a useful therapeutic approach in chemoprevention and treatment of colorectal cancer by the two nutrients occurring naturally in humandiet.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 14:08:12