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Titolo:
An interaction between hypothalamic glucagon-like peptide-1 and macronutrient composition determines food intake in rats
Autore:
Choi, YH; Anderson, GH;
Indirizzi:
Univ Toronto, Fac Med, Dept Nutr Sci, Toronto, ON M5S 3E2, Canada Univ Toronto Toronto ON Canada M5S 3E2 r Sci, Toronto, ON M5S 3E2, Canada
Titolo Testata:
JOURNAL OF NUTRITION
fascicolo: 6, volume: 131, anno: 2001,
pagine: 1819 - 1825
SICI:
0022-3166(200106)131:6<1819:AIBHGP>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
ARTERIAL BLOOD-PRESSURE; NEUROPEPTIDE-Y; PARAVENTRICULAR NUCLEUS; MESSENGER-RNAS; BODY-WEIGHT; 7-36 AMIDE; RECEPTOR AGONISTS; INSULIN RELEASE; FATTY-ACIDS; OBESE RATS;
Keywords:
protein-free, high carbohydrate diet; high protein, low carbohydrate diet; feeding behavior; brain-gut peptide; rats;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
65
Recensione:
Indirizzi per estratti:
Indirizzo: Anderson, GH Univ Toronto, Fac Med, Dept Nutr Sci, Toronto, ON M5S 3E2, Canada Univ Toronto Toronto ON Canada M5S 3E2 o, ON M5S 3E2, Canada
Citazione:
Y.H. Choi e G.H. Anderson, "An interaction between hypothalamic glucagon-like peptide-1 and macronutrient composition determines food intake in rats", J NUTR, 131(6), 2001, pp. 1819-1825

Abstract

Glucagon-like peptide-1 (GLP-1) release in response to food ingestion has been associated with decreased food intake, in the present study, we testedthe hypothesis that the feeding response to GLP-1 injection into the hypothalamic paraventricular nucleus (PVN) is influenced by the macronutrient composition of the food consumed. In the first experiment, rats were injectedwith GLP-1 (0.2 mug) or saline (0.5 muL) in the PVN at dark onset (1800 h), and food intake from a maintenance diet (18% protein) was measured at 1, 2 and 14 h. In Experiment 2, after GLP-1 injection, rats were fed a carbohydrate (protein-free) diet for the first 2 h or gavaged with glucose (1.4 g/5 mt). In Experiment 3, after GLP-1 injection, rats were fed a protein (50%) diet for the first 2 h, or were preloaded with egg albumin (1.0 g). In the last experiment, GLP-1 was given after corn oil gavage (2.4 g). GLP-1 injection resulted in a reduced consumption of the maintenance diet from 2 to 14 h. The decreased food intake from 2 to 14 h after GLP-1 administration occurred after carbohydrate intake, either by meal or preloads, but not after protein intake, either as a meal or preload, A transient interaction of GLP-1 with a corn oil gavage was detected but only in early feeding (0-2 h),We conclude that the effect of GLP-1 injected in the PVN on food intake isinfluenced by the macronutrient composition of the food consumed. Carbohydrate enhances, protein blocks and corn oil has a transient effect on the suppression of food intake caused by GLP-1 in the PVN.

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Documento generato il 26/09/20 alle ore 12:02:24