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Titolo:
Incremental prognostic value of RNA ejection fraction measurements during pharmacologic stress testing: A comparison with clinical and perfusion variables
Autore:
Mast, ST; Shaw, LK; Ravizzini, GC; Chambless, M; Joski, P; Coleman, RE; Borges-Neto, S;
Indirizzi:
Duke Univ, Med & Hlth Syst, Dept Internal Med, Div Cardiol, Durham, NC 27710 USA Duke Univ Durham NC USA 27710 rnal Med, Div Cardiol, Durham, NC 27710 USA Duke Univ, Med & Hlth Syst, Dept Radiol, Div Nucl Med, Durham, NC 27710 USA Duke Univ Durham NC USA 27710 Radiol, Div Nucl Med, Durham, NC 27710 USA
Titolo Testata:
JOURNAL OF NUCLEAR MEDICINE
fascicolo: 6, volume: 42, anno: 2001,
pagine: 871 - 877
SICI:
0161-5505(200106)42:6<871:IPVORE>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORONARY-ARTERY DISEASE; LEFT-VENTRICULAR FUNCTION; EMISSION COMPUTED-TOMOGRAPHY; ACUTE MYOCARDIAL-INFARCTION; TC-99M SESTAMIBI; RADIONUCLIDE ANGIOGRAPHY; RISK STRATIFICATION; TL-201 TOMOGRAPHY; CARDIAC DEATH; EXERCISE;
Keywords:
coronary disease; imaging; perfusion; prognosis; radioisotopes;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Borges-Neto, S Duke Univ, Med & Hlth Syst, Dept Internal Med, Div Cardiol,POB 3949, Durham, NC 27710 USA Duke Univ POB 3949 Durham NC USA 27710 Durham, NC 27710 USA
Citazione:
S.T. Mast et al., "Incremental prognostic value of RNA ejection fraction measurements during pharmacologic stress testing: A comparison with clinical and perfusion variables", J NUCL MED, 42(6), 2001, pp. 871-877

Abstract

This investigation examined the prognostic power of first-pass radionuclide angiocardiography (RNA) ejection fraction compared with clinical information and myocardial perfusion imaging in patients undergoing pharmacologic stress testing. The value of RNA and myocardial perfusion imaging in predicting death or nonfatal myocardial infarction (MI) is well established. However, limited information exists on the usefulness of combined myocardial perfusion imaging and RNA to predict prognosis, especially in patients undergoing pharmacologic stress testing. Methods: We identified 240 patients who underwent pharmacologic stress testing with myocardial perfusion imaging andcombined RNA. The patients were followed for a mean of 1.4 y. Cox proportional hazards models were used to assess the Value in predicting death and MI. Multivariable models were generated to assess the independent incremental predictive value of clinical and nuclear imaging variables. Kaplan-Meier survival and event-free survival estimates were examined in patients with low (less than or equal to 45%) versus high (>45%) ejection fractions. Results: Clinical information, myocardial perfusion imaging, and RNA ejection fraction were significant predictors of the death/Ml composite outcome (chi (2) = 7.4, 14.0, and 21.8, respectively). The addition of myocardial perfusion imaging to the clinical information provided incremental prognostic information (chi (2) = 15.2. ) The addition of RNA ejection fraction provided further predictive information (chi (2) = 22.5). However, when RNA ejection fraction was first added to the clinical information, myocardial perfusion imaging had no incremental prognostic value. Conclusion: For hard cardiac events, RNA ejection fraction provides prognostic information besides that provided by clinical and myocardial perfusion imaging. In patients who cannotexercise and are undergoing noninvasive evaluation with pharmacologic stress testing and myocardial perfusion imaging, ejection fraction should be measured simultaneously for risk assessment optimization.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 09:22:45