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Titolo:
Endothelial proliferation, neoangiogenesis, and potential de novo generation of cerebrovascular malformations
Autore:
Sure, U; Butz, N; Schlegel, J; Siegel, AM; Wakat, JP; Mennel, HD; Bien, S; Bertalanffy, H;
Indirizzi:
Univ Marburg, Dept Neurosurg, D-35033 Marburg, Germany Univ Marburg Marburg Germany D-35033 Neurosurg, D-35033 Marburg, Germany Univ Marburg, Dept Neuroradiol, D-35033 Marburg, Germany Univ Marburg Marburg Germany D-35033 uroradiol, D-35033 Marburg, Germany Univ Marburg, Inst Neuropathol, D-35033 Marburg, Germany Univ Marburg Marburg Germany D-35033 uropathol, D-35033 Marburg, Germany Tech Univ Munich, Inst Pathol, D-8000 Munich, Germany Tech Univ Munich Munich Germany D-8000 st Pathol, D-8000 Munich, Germany Univ Zurich, Dept Neurol, CH-8006 Zurich, Switzerland Univ Zurich ZurichSwitzerland CH-8006 urol, CH-8006 Zurich, Switzerland
Titolo Testata:
JOURNAL OF NEUROSURGERY
fascicolo: 6, volume: 94, anno: 2001,
pagine: 970 - 975
SICI:
0022-3085(200106)94:6<970:EPNAPD>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
CENTRAL-NERVOUS-SYSTEM; CEREBRAL ARTERIOVENOUS-MALFORMATIONS; FAMILIAL CAVERNOUS ANGIOMA; GROWTH-FACTOR RECEPTOR; CELL NUCLEAR ANTIGEN; NATURAL-HISTORY; BRAIN; EXPRESSION; ANGIOGENESIS; CHILDREN;
Keywords:
endothelium; cavernoma; arteriovenous malformation; immunohistochemistry;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
48
Recensione:
Indirizzi per estratti:
Indirizzo: Sure, U Univ Marburg, Dept Neurosurg, Baldingerstr, D-35033 Marburg, Germany Univ Marburg Baldingerstr Marburg Germany D-35033 arburg, Germany
Citazione:
U. Sure et al., "Endothelial proliferation, neoangiogenesis, and potential de novo generation of cerebrovascular malformations", J NEUROSURG, 94(6), 2001, pp. 970-975

Abstract

Object. To date, both arteriovenous malformations (AVMs) and cavernomas have been considered to be congenital malformations. A recent survey of the literature has shown the potential for de novo generation of both familial and sporadic cavernomas as well as AVMs. Therefore, it was of interest to determine the biological behavior of these lesions in detail. Methods. The proliferative and angiogenic capacities of the endothelium of13 cavernomas and 25 AVMs obtained in patients recently treated (1997-1998) at one institution were studied. Immunohistochemical staining for proliferating cell nuclear antigen (PCNA), MIB-1, and vascular endothelial growth factor (VEGF) and its receptor Flk-1 was performed using standard staining procedures. Positive immunostaining of the nuclei of endothelial cells was observed in specimens of both AVMs and cavernomas for PCNA (80% of AVMs and85% of cavernomas), and Flk-1 (80% of AVMs and 31% of cavernomas). Endothelial expression of VEGF in the 18 incompletely embolized AVMs was found in 72% of cases but only in 28% of the seven cases in which patients did not undergo endovascular treatment; it was found in 38% of cavernomas. Endothelial expression of MIB-1 was found in 12% of AVMs but in no cavernomas. Conclusions. These results indicate that there is endothelial proliferation as well as neoangiogenesis in cerebral cavernomas and AVMs. The increasedlevel of angiogenesis in only partially obliterated AVMs underscores the need for radical and complete occlusion of cerebral AVMs to avoid recurrences and further risks of morbidity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/09/20 alle ore 16:06:42