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Titolo:
Microglial activation parallels system degeneration in progressive supranuclear palsy and corticobasal degeneration
Autore:
Ishizawa, K; Dickson, DW;
Indirizzi:
Mayo Clin, Dept Pathol, Jacksonville, FL 32224 USA Mayo Clin JacksonvilleFL USA 32224 pt Pathol, Jacksonville, FL 32224 USA
Titolo Testata:
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
fascicolo: 6, volume: 60, anno: 2001,
pagine: 647 - 657
SICI:
0022-3069(200106)60:6<647:MAPSDI>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
RICHARDSON-OLSZEWSKI-SYNDROME; ALZHEIMERS-DISEASE; GRUMOSE DEGENERATION; TAU; PATHOLOGY; CRITERIA; PARKINSONS; PROTEIN;
Keywords:
corticobasal degeneration; HLA-DR; image analysis; immunohistochemistry; microglia; progressive supranuclear palsy; tau;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Dickson, DW Mayo Clin, Dept Pathol, 4500 San Pablo Rd, Jacksonville, FL 32224 USA Mayo Clin 4500 San Pablo Rd Jacksonville FL USA 32224 2224 USA
Citazione:
K. Ishizawa e D.W. Dickson, "Microglial activation parallels system degeneration in progressive supranuclear palsy and corticobasal degeneration", J NE EXP NE, 60(6), 2001, pp. 647-657

Abstract

The rule of microglia in progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD) is unknown. To address this issue we examined 10 cases of PSP, 5 cases of CBD, and 4 normal controls. Microglial and tau burdens were determined with image analysis on brain sections that had been immunostained with monoclonal antibodies to HLA-DR and phospho-tau. We found that microglial activation was greater in PSP and CBD than normal controls, and that the microglial burden correlated with the tau burden in most areas. There were distinct patterns of microglial activation and tau pathology inPSP and CBD. with PSP showing more pathology in infratentorial structures and CBD showing more pathology in supratentorial structures. These results support the notion that PSP and CBD are distinct clinicopathologic entities. Microglial activation was not well correlated with tau pathology in the brainstem of PSP. which suggests that brainstem pathology in PSP is not exclusively due to tau pathology. While the results do not necessarily support 3 direct causal link between microglial activation and neurodegeneration inPSP or CBD, they nevertheless suggest that microglia play a role in disease pathogenesis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 18:32:15