Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Mitogenic signaling and the relationship to cell cycle regulation in astrocytomas
Autore:
Besson, A; Yong, VW;
Indirizzi:
Univ Calgary, Dept Oncol, Calgary, AB T2N 4N1, Canada Univ Calgary Calgary AB Canada T2N 4N1 Oncol, Calgary, AB T2N 4N1, Canada Univ Calgary, Dept Clin Neurosci, Calgary, AB, Canada Univ Calgary Calgary AB Canada , Dept Clin Neurosci, Calgary, AB, Canada
Titolo Testata:
JOURNAL OF NEURO-ONCOLOGY
fascicolo: 3, volume: 51, anno: 2001,
pagine: 245 - 264
SICI:
0167-594X(200102)51:3<245:MSATRT>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
EPIDERMAL-GROWTH-FACTOR; PROTEIN-KINASE-C; HUMAN GLIOBLASTOMA CELLS; FOCAL ADHESION KINASE; HUMAN GLIOMA-CELLS; TUMOR-SUPPRESSOR PTEN; FACTOR RECEPTOR GENE; CONFERS ENHANCED TUMORIGENICITY; POLYMERASE-CHAIN-REACTION; HUMAN-MALIGNANT GLIOMAS;
Keywords:
PDGFR; EGFR; PKC; cell cycle regulation; Ras; integrin; PTEN/MMAC1/TEP1;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
148
Recensione:
Indirizzi per estratti:
Indirizzo: Yong, VW Univ Calgary, Dept Oncol, 3330 Hosp Dr NW, Calgary, AB T2N 4N1, Canada Univ Calgary 3330 Hosp Dr NW Calgary AB Canada T2N 4N1 N1, Canada
Citazione:
A. Besson e V.W. Yong, "Mitogenic signaling and the relationship to cell cycle regulation in astrocytomas", J NEURO-ONC, 51(3), 2001, pp. 245-264

Abstract

The activity and regulation of a number of mitogenic signaling pathways isaberrant in astrocytomas, and this is thought to play a crucial role in the development of these tumors. The cascade of events leading to the formation and the progression from low-grade to high-grade astrocytomas is well characterized. These events include activating mutations, amplification, and overexpression of various growth factor receptors (e.g. epidermal growth factor receptor (EGFR), platelet derived growth factor receptor (PDGFR), c-Met), signaling intermediates (e.g. Ras and Protein kinase C (PKC)), and cellcycle regulatory molecules (e.g. mouse double minute-2 (Mdm2), cyclin-dependent kinase-4 (CDK4), and CDK6), that positively regulate proliferation and cell cycle progression. Inactivating mutations and deletions of signalingand cell cycle regulatory molecules that negatively regulate proliferationand cell cycle progression (e.g. p53, p16/INK4a, p14/ARF, p15/INK4b, retinoblastoma protein (Rb), and Phosphatase and tensin homologue deleted from chromosome 10 (PTEN)) also participate actively in the development of the transformed phenotype. Several mitogenic pathways are also stimulated via an autocrine loop, with astrocytoma cells expressing both the receptors and the respective cognate ligand. Due to the multitude of factors involved in astrocytoma pathogenesis, attempts to target a single pathway have not given satisfactory results. The simultaneous targeting of several pathways or thetargeting of signaling intermediates, such as Ras or PKC, situated downstream of many growth factor receptor signaling pathways may show more efficacy in astrocytoma therapy. We will give an overview of how the combination of these aberrations drive astrocytoma cells into a relentless proliferationand how these signaling molecules may constitute relevant therapeutic targets.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/09/20 alle ore 12:32:41