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Titolo:
The INK4A/ARF locus: Role in cell cycle control and apoptosis and implications for glioma growth
Autore:
Ivanchuk, SM; Mondal, S; Dirks, PB; Rutka, JT;
Indirizzi:
Univ Toronto, Hosp Sick Children, Div Neurosurg, Toronto, ON M5G 1X8, Canada Univ Toronto Toronto ON Canada M5G 1X8 osurg, Toronto, ON M5G 1X8, Canada Univ Toronto, Hosp Sick Children, Arthur & Sonia Labatt Brain Tumour Res Ctr, Toronto, ON M5G 1X8, Canada Univ Toronto Toronto ON Canada M5G 1X8 s Ctr, Toronto, ON M5G 1X8, Canada
Titolo Testata:
JOURNAL OF NEURO-ONCOLOGY
fascicolo: 3, volume: 51, anno: 2001,
pagine: 219 - 229
SICI:
0167-594X(200102)51:3<219:TILRIC>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
ARF TUMOR-SUPPRESSOR; DEPENDENT KINASE CDK6; RETINOBLASTOMA-PROTEIN; CPG ISLAND; HUMAN GLIOBLASTOMA; HUMAN FIBROBLASTS; INHIBITOR P16; GENE-PRODUCT; INK4 FAMILY; WILD-TYPE;
Keywords:
apoptosis; growth arrest; INK4A/ARF; p53; pRB; tumour suppressor;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
70
Recensione:
Indirizzi per estratti:
Indirizzo: Dirks, PB Univ Toronto, Hosp Sick Children, Div Neurosurg, 555 Univ Ave, Toronto, ONM5G 1X8, Canada Univ Toronto 555 Univ Ave Toronto ON Canada M5G 1X8 1X8, Canada
Citazione:
S.M. Ivanchuk et al., "The INK4A/ARF locus: Role in cell cycle control and apoptosis and implications for glioma growth", J NEURO-ONC, 51(3), 2001, pp. 219-229

Abstract

The unique INK4A/ARF locus at chromosome 9p21 encodes two distinct proteins that intimately link the pRB and p53 tumour suppressor pathways. p16(INK4A) has been identified as an inhibitor of the cell cycle, capable of inducing arrest in G1 phase. p14/p19(ARF) on the other hand can induce both G1 and G2 arrest due to its stabilizing effects on the p53 transcription factor. In addition to their roles in growth arrest, both proteins are involved incellular senescence and apoptosis. The frequent mutation or deletion of INK4A/ARF in human tumours as well as the occurence of tumours in the murine knockout models have identified both p16 and ARF as bona fide tumour suppressors.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/08/20 alle ore 08:35:05