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Titolo:
Cip/Kip cell-cycle inhibitors: A neuro-oncological perspective
Autore:
Mainprize, TG; Taylor, MD; Rutka, JT; Dirks, PB;
Indirizzi:
Univ Toronto, Hosp Sick Children, Div Neurosurg, Toronto, ON M5G 1X8, Canada Univ Toronto Toronto ON Canada M5G 1X8 osurg, Toronto, ON M5G 1X8, Canada Univ Toronto, Hosp Sick Children, Arthur & Sonia Labatt Brain Tumour Res Ctr, Toronto, ON M5G 1X8, Canada Univ Toronto Toronto ON Canada M5G 1X8 s Ctr, Toronto, ON M5G 1X8, Canada
Titolo Testata:
JOURNAL OF NEURO-ONCOLOGY
fascicolo: 3, volume: 51, anno: 2001,
pagine: 205 - 218
SICI:
0167-594X(200102)51:3<205:CCIANP>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEPENDENT-KINASE INHIBITOR; BECKWITH-WIEDEMANN-SYNDROME; GROWTH-FACTOR-BETA; HUMAN-MALIGNANT GLIOMA; TUMOR-SUPPRESSOR GENE; CDK INHIBITOR; P21(WAF1/CIP1) EXPRESSION; MICE LACKING; P27(KIP1) EXPRESSION; REDUCED EXPRESSION;
Keywords:
CKI; cell-cycle inhibitors; p21(Cip1); p27(Kip1); p57(Kip2);
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
152
Recensione:
Indirizzi per estratti:
Indirizzo: Dirks, PB Univ Toronto, Hosp Sick Children, Div Neurosurg, 555 Univ Ave, Toronto, ONM5G 1X8, Canada Univ Toronto 555 Univ Ave Toronto ON Canada M5G 1X8 1X8, Canada
Citazione:
T.G. Mainprize et al., "Cip/Kip cell-cycle inhibitors: A neuro-oncological perspective", J NEURO-ONC, 51(3), 2001, pp. 205-218

Abstract

The cell cycle is a precisely controlled cellular program that ensures normal cellular proliferation and development. The cyclin-dependant kinases (CDK) are molecules central to the continued progression through the cell-cycle checkpoints and as such are regulated by various mechanisms including cyclin levels, phosphorylation/dephosphorylation and cyclin-dependant kinase inhibitors (CKI). The CKIs are grouped into two families based on their structure and function, four Ink4 CKIs and three Cip/Kip CKIs. Abnormalities in these proteins can give rise to developmental defects and cancer. In thisreview, we will discuss the biochemistry and cell biology of the each of the Cip/Kip CKIs, their role in development as evidenced by targeted mutations in mice, and their role as possible tumor suppressor genes.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 06:10:19