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Titolo:
Cubilin, a multifunctional epithelial receptor: an overview
Autore:
Kozyraki, R;
Indirizzi:
CHU St Antoine, INSERM, U538, F-75012 Paris, France CHU St Antoine ParisFrance F-75012 INSERM, U538, F-75012 Paris, France CHU St Antoine, Lab Embryol, F-75012 Paris, France CHU St Antoine Paris France F-75012 , Lab Embryol, F-75012 Paris, France
Titolo Testata:
JOURNAL OF MOLECULAR MEDICINE-JMM
fascicolo: 4, volume: 79, anno: 2001,
pagine: 161 - 167
SICI:
0946-2716(200105)79:4<161:CAMERA>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
HIGH-DENSITY-LIPOPROTEIN; FACTOR-COBALAMIN RECEPTOR; APOLIPOPROTEIN-A-I; VISCERAL YOLK-SAC; FACTOR VITAMIN-B-12 RECEPTOR; BRUSH-BORDER EXPRESSION; LIPID TRANSFER PROTEINS; RENAL PROXIMAL TUBULE; TERATOGENIC ANTIBODIES; HEREDITARY MEGALOBLASTIC-ANEMIA-1;
Keywords:
cubilin; megalin; vitamin B-12; endocytosis; high-density lipoprotein;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
61
Recensione:
Indirizzi per estratti:
Indirizzo: Kozyraki, R CHU St Antoine, INSERM, U538, 27 Rue Chaligny, F-75012 Paris, France CHU St Antoine 27 Rue Chaligny Paris France F-75012 s, France
Citazione:
R. Kozyraki, "Cubilin, a multifunctional epithelial receptor: an overview", J MOL MED-J, 79(4), 2001, pp. 161-167

Abstract

Cubilin is a 460-kDa endocytic receptor coexpressed with megalin, a multiligand receptor of the low-density lipoprotein receptor gene family, at the apical pole of epithelial cells in the renal proximal convoluted tubule, visceral yolk sac, ileum, and placenta. The structure of cubilin is unique: it lacks a transmembrane domain and requires megalin fur its internalization. The accumulation of 27 interactive CUB domains provides the potential formultiple, possibly independent interactions and functions, Cubilin is involved in the intestinal absorption of vitamin B-12, the catabolism of apolipoprotein A-I by the proximal convoluted tubule and more generally in renal protein reabsorption. The role of cubilin on fetomaternal interfaces is notdefined but may be related to its ability to bind and internalize high density lipoproteins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 10:30:31