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Titolo:
Bupropion hydrochloride: The development of a chiral separation using a chiral AGP column
Autore:
Munro, J; Gormley, JP; Walker, TA;
Indirizzi:
Geneva Pharmaceut Inc, Preformulat Dept, Broomfield, CO 80038 USA Geneva Pharmaceut Inc Broomfield CO USA 80038 t, Broomfield, CO 80038 USA
Titolo Testata:
JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES
fascicolo: 3, volume: 24, anno: 2001,
pagine: 327 - 339
SICI:
1082-6076(2001)24:3<327:BHTDOA>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
ALPHA(1)-ACID GLYCOPROTEIN COLUMN; BONDED STATIONARY PHASE; HUMAN-SERUM-ALBUMIN; ALPHA-1-ACID GLYCOPROTEIN; DYNAMIC MODIFICATION; BONDING PROPERTIES; CATIONIC DRUGS; HUMAN-PLASMA; BASIC DRUGS; ENANTIOMERS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Physical, Chemical & Earth Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Walker, TA Geneva Pharmaceut Inc, Preformulat Dept, 2655 W Midway Blvd,POB446, Broomfield, CO 80038 USA Geneva Pharmaceut Inc 2655 W Midway Blvd,POB446 Broomfield CO USA 80038
Citazione:
J. Munro et al., "Bupropion hydrochloride: The development of a chiral separation using a chiral AGP column", J LIQ CHR R, 24(3), 2001, pp. 327-339

Abstract

A chiral high-performance liquid chromatographic separation was developed for bupropion active ingredient. The mobile phase parameters that may influence the separation were studied and included: mobile phase pH, type and concentration of organic modifier, type and concentration of buffer, amount of analyte injected, and column temperature. The optimized chiral separationbaseline resolved the two enantiomers in less than 10 minutes. Method validation was also performed for the separation. The method was found to be linear over a range of 0.5 mug/g to 99.8 mug/g with a correlationcoefficient greater than 0.999. The limit of detection was determined to be 0.25 mug/g while the limit of quantitation was found to be 0.5 mug/g. Method precision was found to be 0.8% and 1.9% for the two enantiomers, while the system precision was found to be 0.4% and 0.5% for the two enantiomers.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 06:36:41