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Titolo:
Capillary electrophoretic method for the determination of etodolac in pharmaceutical tablet formulation
Autore:
Dogrukol-Ak, D; Kutluk, OB; Tuncel, M; Aboul-Enein, HY;
Indirizzi:
King Faisal Specialist Hosp & Res Ctr, Biol & Med Res Dept MBC03, Pharmaceut Anal Lab, Riyadh 11211, Saudi Arabia King Faisal Specialist Hosp & Res Ctr Riyadh Saudi Arabia 11211 i Arabia Univ Anadolu, Fac Pharm, Dept Analyt Chem, TR-26470 Tepebasi, Eskisehir, Turkey Univ Anadolu Tepebasi Eskisehir Turkey TR-26470 pebasi, Eskisehir, Turkey
Titolo Testata:
JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES
fascicolo: 6, volume: 24, anno: 2001,
pagine: 773 - 780
SICI:
1082-6076(2001)24:6<773:CEMFTD>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
PERFORMANCE LIQUID-CHROMATOGRAPHY; MASS-SPECTROMETRY; HUMAN-PLASMA; IDENTIFICATION; DRUGS; DERIVATIZATION; ENANTIOMERS; URINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Physical, Chemical & Earth Sciences
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Aboul-Enein, HY King Faisal Specialist Hosp & Res Ctr, Biol & Med Res DeptMBC03, Pharmaceut Anal Lab, POB 3354, Riyadh 11211, Saudi Arabia King Faisal Specialist Hosp & Res Ctr POB 3354 Riyadh Saudi Arabia 11211
Citazione:
D. Dogrukol-Ak et al., "Capillary electrophoretic method for the determination of etodolac in pharmaceutical tablet formulation", J LIQ CHR R, 24(6), 2001, pp. 773-780

Abstract

Etodolac (ETO) is a nonsteroidal anti-inflammatory drug with anti-inflammatory analgesic, and antipyretic activities. A capillary electrophoretic method for the determination of etodolac in a pharmaceutical preparation is described. ETO and diflunisal as an internal standard (IS) were well migratedin the background electrolyte of 10 mM berate at pH 9.3, using a fused silica capillary. The separation was achieved by applying 25 kV, detecting at 226 nm, and injecting the sample for 0.5 s. The average migration times t(m) (relative standard deviation percentage) of ETO and IS were 7.1 (0.4) and8.3 (0.5) min, respectively. Highly repeatable results were also obtained for areas of the peaks and peak normalization ratio (PNETO/PNIS). Well-correlated linearity was found in a concentration range of 1 x 10(-5)-2 x 10(-4) M. Intraday and interday calibration studies were performed, and reliableresults were obtained. Limit of detection and limit of quantitation were 3.2 x 10(-6) and 9.7 x 10(-6) M, respectively. The proposed method was successfully applied for the analysis of etodolac in the pharmaceutical tablet formulation. The method proved to be simple, reproducible, precise, and fast, since analysis can be performed in less than 10 min.

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Documento generato il 22/01/20 alle ore 06:49:23