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Titolo:
Chiral capillary electrophoretic separation of selected drugs and metabolites using sulfated beta-cyclodextrin
Autore:
Bonato, PS; Jabor, VAP; Paias, FO; Lanchote, VL;
Indirizzi:
Univ Sao Paulo, Fac Ciencias Farmaceut Ribeirao Preto, BR-14040903 Ribeirao Preto, Brazil Univ Sao Paulo Ribeirao Preto Brazil BR-14040903 BCibeirao Preto, Brazil Univ Sao Paulo, Fac Filosofia Ciencias & Letras Ribeirao Preto, BR-14040901 Ribeirao Preto, Brazil Univ Sao Paulo Ribeirao Preto Brazil BR-14040901BCibeirao Preto, Brazil
Titolo Testata:
JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES
fascicolo: 8, volume: 24, anno: 2001,
pagine: 1115 - 1131
SICI:
1082-6076(2001)24:8<1115:CCESOS>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENANTIOMERIC SEPARATIONS; LIQUID-CHROMATOGRAPHY; NEUTRAL CYCLODEXTRINS; ENANTIOSELECTIVE DETERMINATION; NORFLUOXETINE; FLUOXETINE; MIXTURES; SERUM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Physical, Chemical & Earth Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Bonato, PS Univ Sao Paulo, Fac Ciencias Farmaceut Ribeirao Preto, Ave CafeS-N, BR-14040903 Ribeirao Preto, Brazil Univ Sao Paulo Ave Cafe S-N Ribeirao Preto Brazil BR-14040903 BC
Citazione:
P.S. Bonato et al., "Chiral capillary electrophoretic separation of selected drugs and metabolites using sulfated beta-cyclodextrin", J LIQ CHR R, 24(8), 2001, pp. 1115-1131

Abstract

In this paper, we report the chiral separation of some drugs and their metabolites using sulfated beta -cyclodextrin, a powerful chiral selector thathas proven to be highly efficient for the separation of chiral drugs, alone or in combination, with other chiral additives. Praziquantel, its metabolite trans-4-hydroxypraziquantel, and albendazole sulfoxide are neutral compounds and could be separated at basic pH (8-10). The simultaneous chiral separation of praziquantel and its metabolite enantiomers was only possible by the addition of sodium deoxycholate to the running buffer. Fluoxetine, disopyramide, and mexiletine, as well as their metabolites are basic compounds and were separated by appropriate selection ofthe running buffer pH and CD concentration. In addition, the effects of the experimental parameters, such as concentration of sulfated beta -cyclodextrin, pH and buffer concentration, temperature, and voltage were also evaluated. Among the several parameters studied, the concentration of the chiral selector and the pH were the most important to obtain the chiral separation of the selected drugs and metabolites.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 22:22:17