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Titolo:
Plasmacytoma with aberrant expression of myeloid markers, T-cell markers, and cytokeratin
Autore:
Shin, JS; Stopyra, GA; Warhol, MJ; Multhaupt, HAB;
Indirizzi:
Penn Hosp, Dept Pathol, Philadelphia, PA 19107 USA Penn Hosp PhiladelphiaPA USA 19107 pt Pathol, Philadelphia, PA 19107 USA
Titolo Testata:
JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY
fascicolo: 6, volume: 49, anno: 2001,
pagine: 791 - 792
SICI:
0022-1554(200106)49:6<791:PWAEOM>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
MULTIPLE-MYELOMA; IMMUNOBLASTIC LYMPHOMA; ANTIGEN;
Keywords:
plasmacytoma; mitosis; immunophenotyping; flow cytometry;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
11
Recensione:
Indirizzi per estratti:
Indirizzo: Multhaupt, HAB Penn Hosp, Dept Pathol, 800 Spruce St, Philadelphia, PA 19107 USA Penn Hosp 800 Spruce St Philadelphia PA USA 19107 19107 USA
Citazione:
J.S. Shin et al., "Plasmacytoma with aberrant expression of myeloid markers, T-cell markers, and cytokeratin", J HIST CYTO, 49(6), 2001, pp. 791-792

Abstract

Plasmacytomas are localized neoplastic proliferations of monoclonal plasmacells. When multifocal, the process is referred to as multiple myeloma. These lesions exhibit a pattern of antigen expression and cytomorphology thatusually leads to a ready diagnosis. However, potentially troublesome variations in immunophenotype occur. We describe a case of a plasmacytoma from apatient who presented with sudden onset of pain and a lytic lesion of the left proximal humerus. Hematoxylin and eosin-stained sections showed a lymphoproliferative lesion composed of large lymphoid cells, some with plasmacytoid and immunoblastic features. The lesion also showed significant mitoticactivity. Immunohistochemical staining was positive for CD45 (LCA), CD56 (N-CAM), CD43 (MT1), and cytokeratin CAM5.2. There was also clonal staining for X light chains. In addition, flow cytometric analysis showed positivityfor myeloid markers such as CD13, CD33, CD38, and CD138. Significant negative markers include CD20 (L26), CD45RO (UCHL-1), and CD79 alpha. The unusual phenotypic features of this plasmacytoma illustrate potential diagnostic pitfalls. It is important to fully study such lesions to correctly classifythem, because this has significant impact on prognosis and management.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/07/20 alle ore 13:24:43