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Titolo:
Increased basal levels of plasma nitric oxide in Type 2 diabetic subjects - Relationship to microvascular complications
Autore:
Maejima, K; Nakano, S; Himeno, M; Tsuda, S; Makiishi, H; Ito, T; Nakagawa, A; Kigoshi, T; Ishibashi, T; Nishio, M; Uchida, K;
Indirizzi:
Kanazawa Med Univ, Dept Internal Med, Div Endocrinol, Uchinada, Ishikawa 9200293, Japan Kanazawa Med Univ Uchinada Ishikawa Japan 9200293 Ishikawa 9200293, Japan
Titolo Testata:
JOURNAL OF DIABETES AND ITS COMPLICATIONS
fascicolo: 3, volume: 15, anno: 2001,
pagine: 135 - 143
SICI:
1056-8727(200105/06)15:3<135:IBLOPN>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENDOTHELIUM-DEPENDENT VASODILATION; GLYCATION END-PRODUCTS; HIGH GLUCOSE; SYNTHASE EXPRESSION; OXIDATIVE STRESS; SMOOTH-MUSCLE; CELLS; MELLITUS; DYSFUNCTION; HYPERFILTRATION;
Keywords:
nitric oxide; HPLC-Griess method; diabetes mellitus; microvascular complications; oxidative stress;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Nakano, S Kanazawa Med Univ, Dept Internal Med, Div Endocrinol, 1-1 Daigaku, Uchinada, Ishikawa 9200293, Japan Kanazawa Med Univ 1-1 Daigaku UchinadaIshikawa Japan 9200293 an
Citazione:
K. Maejima et al., "Increased basal levels of plasma nitric oxide in Type 2 diabetic subjects - Relationship to microvascular complications", J DIABET C, 15(3), 2001, pp. 135-143

Abstract

To assess the underlying mechanisms of decreased endothelial function and advanced vascular complications in patients with Type 2 diabetes, we determined basal levels of plasma nitric oxide (NOx: NO2 (-) and NO3 (-)) using anewly developed high-performance liquid chromatography (HPLC)-Griess method in hospitalized 129 diabetic and 76 nondiabetic subjects, and examined their clinical characteristics. Serum lipid peroxide and advanced glycation end products (AGEs) as markers of oxidative stress were also measured, and intima-media thickness (IMT) of the carotid artery was evaluated as a markerof atherosclerosis. In diabetic subjects, microvascular complications werenewly evaluated during their admission. There were no differences in age or sex between the diabetic and nondiabetic subjects. Although there was no difference in basal plasma NO2 (-) levels between the two groups, the basallevels of plasma NO3 (-) in diabetic subjects were significantly higher than those in nondiabetic subjects. Plasma NOx levels in neither diabetic nornondiabetic subjects correlated with serum lipids, HbAlc, or IMT. In diabetic subjects, plasma NO3 (-) levels were related not only to the presence of hypertension but also to advanced microvascular complications. Moreover, plasma NO3 (-) levels were positively correlated with both serum lipid peroxide and AGEs. Multiple regression analysis revealed that serum AGEs level was strongly associated with plasma NO3 (-) level. Thus, the findings are consistent with the hypothesis that decreased endothelium-dependent vasodilation in diabetic subjects is associated with the impaired action of NO secondary to its inactivation resulting from increased oxidative stress, ratherthan decreased NO production from vascular endothelium, and that abnormal NO metabolism is related to advanced diabetic microvascular complications. (C) 2001 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/09/20 alle ore 09:19:40