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Titolo:
Delayed gastric emptying rate in Type 1 diabetics with cardiac autonomic neuropathy
Autore:
Darwiche, G; Almer, LO; Bjorgell, O; Cederholm, C; Nilsson, P;
Indirizzi:
Univ Lund, Malmo Univ Hosp, Dept Internal Med, S-20502 Malmo, Sweden Univ Lund Malmo Sweden S-20502 Dept Internal Med, S-20502 Malmo, Sweden
Titolo Testata:
JOURNAL OF DIABETES AND ITS COMPLICATIONS
fascicolo: 3, volume: 15, anno: 2001,
pagine: 128 - 134
SICI:
1056-8727(200105/06)15:3<128:DGERIT>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEALTHY-SUBJECTS; HEART-RATE; HYPOGLYCEMIA INCREASES; BLOOD-GLUCOSE; MELLITUS; GASTROPARESIS; HYPERGLYCEMIA; AGE; DURATION; SMOKING;
Keywords:
gastric emptying; diabetes mellitus; autonomic nervous function; cardiac autonomic neuropathy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: Darwiche, G Univ Lund, Malmo Univ Hosp, Dept Internal Med, S-20502 Malmo, Sweden Univ Lund Malmo Sweden S-20502 al Med, S-20502 Malmo, Sweden
Citazione:
G. Darwiche et al., "Delayed gastric emptying rate in Type 1 diabetics with cardiac autonomic neuropathy", J DIABET C, 15(3), 2001, pp. 128-134

Abstract

Gastroparesis is a frequent complication of longstanding diabetes and has been attributed to vagal nerve dysfunction, occurring as part of a generalized autonomic neuropathy. We wanted to clarify the relationship between delayed gastric emptying (GE) and cardiac autonomic neuropathy (CAN) in type Idiabetics. Using a standardized ultrasound technique, GE was studied in 20type 1 diabetic patients with poor glycaemic control despite good compliance and 10 normal healthy volunteers (Croup I). Measurements of GE were doneon condition that the fasting blood glucose was 3.5-9.0 mmol/l. Diabetic patients were classified into two groups according to the absence (Group 2) or presence (Group 3) of CAN, using the deep breathing test (E:l ratio) to evaluate parasympathetic vagal nerve function. Age-related reference valueswere used to evaluate the indices of CAN. The supine resting hear? rate was also checked, and the patients were asked for symptoms of gastroparesis. The three groups were similar in terms of sex and smoking habits, and therewas no significant difference regarding the age and body mass index (BMI). The mean duration of diabetes and the glycaemic control (HbAlc) was insignificant between patients in Groups 2 and 3. Diabetic patients in Group 3 showed lower gastric emptying rates (GER) than the healthy volunteers in Group 1 (median GER 16% vs. 63%, P < .01) and the patients in Group 2 (median GER 16% vs. 54%, P < .01). No significant difference in GER could be seen between patients in Group 2 and subjects in Group 1 (median GER 54% vs. 63%, P=.08). Assuming that GER < 45% indicated a delayed GE, 8 of IO patients inGroup 3 had delayed GE compared to only 3 of IO patients in Group 2. Therewere disagreements between symptoms of gastroparesis and delayed GE. We conclude that there is a significant lower GER in type 1 diabetic patients with CAN than in those without, unrelated to symptoms of gastroparesis. (C) 2001 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 16:36:51