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Titolo:
Insulin-like growth factor 1 and oestradiol promote cell proliferation of MCF-7 breast cancer cells: new insights into their synergistic effects
Autore:
Dupont, J; Le Roith, D;
Indirizzi:
NIDDK, Clin Endocrinol Branch, NIH, Bethesda, MD 20892 USA NIDDK BethesdaMD USA 20892 ndocrinol Branch, NIH, Bethesda, MD 20892 USA
Titolo Testata:
JOURNAL OF CLINICAL PATHOLOGY-MOLECULAR PATHOLOGY
fascicolo: 3, volume: 54, anno: 2001,
pagine: 149 - 154
SICI:
1366-8714(200106)54:3<149:IGF1AO>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
I SOMATOMEDIN RECEPTOR; ESTROGEN-RECEPTOR; CYCLIN D1; IGF-I; CDK INHIBITORS; KINASE; MICE; EXPRESSION; PROTEIN; SYSTEM;
Keywords:
breast cancer; oestrogen receptor; insulinlike growth factor 1 receptor; cell cycle;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Le Roith, D NIDDK, Clin Endocrinol Branch, NIH, Room 8D12,Bldg 10, Bethesda, MD 20892 USA NIDDK Room 8D12,Bldg 10 Bethesda MD USA 20892 da, MD 20892 USA
Citazione:
J. Dupont e D. Le Roith, "Insulin-like growth factor 1 and oestradiol promote cell proliferation of MCF-7 breast cancer cells: new insights into their synergistic effects", J CL PATH-M, 54(3), 2001, pp. 149-154

Abstract

In MCF-7 breast cancer cells, the insulinlike growth factor 1 receptor (IGF-1R) and the oestrogen receptor (ER) are coexpressed and the two signalling systems are engaged in a crosstalk that results in synergistic growth. However, coupling between the signalling cascades is poorly understood. Oestradiol enhances IGF-1R signalling by inducing the expression of insulin receptor substrate 1 (IRS-1), a substrate of the IGF-1R. Oestradiol induced expression of IRS-1 results in enhanced tyrosine phosphorylation of IRS-1 after IGF-1 stimulation, followed by enhanced mitogen activated protein kinase,phosphoinositide 3 ' kinase, and Akt activation. Oestradiol can also potentiate the effect of IGF-1 on the expression of cyclin D1 and cyclin E, and on the phosphorylation of the retinoblastoma protein (RB). These effects are greatly diminished in SX13 cells, which exhibit a 50% reduction in IGF-1Rexpression but few functional IGF-1Rs at the surface. Oestradiol and IGF-1regulate the expression of two cyclin dependent kinase inhibitors, p21 andp27, differently. Whereas IGF-1 increases p21 expression and reduces p27 expression, oestradiol has no effect on p21. In summary, in MCF-7 cells, oestrogen potentiates the effect of IGF-1 on IGF-1R signalling and its effectson certain cell cycle components.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/11/20 alle ore 11:44:00