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Titolo:
Signalling pathways involved in antiproliferative effects of IGFBP-3: a review
Autore:
Baxter, RC;
Indirizzi:
Univ Sydney, Royal N Shore Hosp, Kolling Inst Med Res, St Leonards, NSW 2065, Australia Univ Sydney St Leonards NSW Australia 2065 Leonards, NSW 2065, Australia
Titolo Testata:
JOURNAL OF CLINICAL PATHOLOGY-MOLECULAR PATHOLOGY
fascicolo: 3, volume: 54, anno: 2001,
pagine: 145 - 148
SICI:
1366-8714(200106)54:3<145:SPIIAE>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
FACTOR-BINDING PROTEIN-3; BREAST-CANCER CELLS; GROWTH-FACTOR BINDING-PROTEIN-3; HUMAN-SKIN FIBROBLASTS; NUCLEAR TRANSPORT; ONCOGENIC RAS; APOPTOSIS; RECEPTOR; DEATH; RESISTANCE;
Keywords:
insulin-like growth factor binding protein-3; signalling pathway; apoptosis; transforming growth factor beta;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Baxter, RC Univ Sydney, Royal N Shore Hosp, Kolling Inst Med Res, St Leonards, NSW 2065, Australia Univ Sydney St Leonards NSW Australia 2065 NSW 2065, Australia
Citazione:
R.C. Baxter, "Signalling pathways involved in antiproliferative effects of IGFBP-3: a review", J CL PATH-M, 54(3), 2001, pp. 145-148

Abstract

Insulin-like growth factor binding protein-3 (IGFBP-3), the major circulating carrier protein for IGFs, is also active in the cellular environment asa potent antiproliferative agent. It appears to function both by cell cycle blockade and the induction of apoptosis. Transfection of p53 negative T47D breast cancer cells to express IGFBP-3 leads to induction of the apoptotic protein bar and an increase in sensitivity to ionising radiation. IGFBP-3can be transported to the nucleus by an importin beta mediated mechanism, where it has been shown to interact with the retinoid X receptor a and possibly other nuclear elements. Expression of oncogenic ras is associated withresistance to exogenous IGFBP-3, the effect being reversible by inhibitionof mitogen activated protein (MAP) kinase phosphorylation. IGFBP-3 antiproliferative signalling appears to require an active transforming growth factor beta (TGF-beta) signalling pathway, and IGFBP-3 stimulates phosphorylation of the TGF-beta signalling intermediates Smad2 and Smad3. These recent findings all point to a complex intracellular mode of action of IGFBP-3, which will need to be better understood if anti-cancer treatments are to take advantage of the antiproliferative activity of IGFBP-3.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/09/20 alle ore 18:29:41