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Titolo:
The IGF system in thyroid cancer: new concepts
Autore:
Vella, V; Sciacca, L; Pandini, G; Mineo, R; Squatrito, S; Vigneri, R; Belfiore, A;
Indirizzi:
Univ Catanzaro Magna Graecia, Policlin Mater Domini, Dipartimento Med Sperimentale & Clin, Cattedra Endocrinol & Malattie Metab, Catanzaro, Italy Univ Catanzaro Magna Graecia Catanzaro Italy ie Metab, Catanzaro, Italy IMO, Catania, Italy IMO Catania ItalyIMO, Catania, Italy Univ Catania, Osped Garibaldi, Ist Med Interna Malattie Endocrine & Metab,Cattedra Endocrinol, Catania, Italy Univ Catania Catania Italy & Metab,Cattedra Endocrinol, Catania, Italy
Titolo Testata:
JOURNAL OF CLINICAL PATHOLOGY-MOLECULAR PATHOLOGY
fascicolo: 3, volume: 54, anno: 2001,
pagine: 121 - 124
SICI:
1366-8714(200106)54:3<121:TISITC>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
GROWTH-FACTOR-I; INSULIN-RECEPTOR; BREAST-CANCER; HYBRID RECEPTORS; CELL-PROLIFERATION; HIGH-AFFINITY; EXPRESSION; TUMORS; DIFFERENTIATION; OVEREXPRESSION;
Keywords:
insulin-like growth factor system; insulin receptor; insulin-like growth factor I receptor;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Belfiore, A Univ Catanzaro Magna Graecia, Policlin Mater Domini, Dipartimento Med Sperimentale & Clin, Cattedra Endocrinol & Malattie Metab, Catanzaro, Italy Univ Catanzaro Magna Graecia Catanzaro Italy tanzaro, Italy
Citazione:
V. Vella et al., "The IGF system in thyroid cancer: new concepts", J CL PATH-M, 54(3), 2001, pp. 121-124

Abstract

In recent years, the activation of the insulin-like growth factor (IGF) system in cancer has emerged as a key factor for tumour progression and resistance to apoptosis. Therefore, a variety of strategies have been developed to block the type I IGF receptor (IGF-I-R), which is thought to mediate thebiological effects of both IGF-I and IGF-II. However, recent data suggest that the IGF signalling system is complex and that other receptors are involved. To unravel the complexity of the IGF system in thyroid cancer, IGF-I[and IGF-II production, and the expression and function of their cognate receptors were studied. Both IGFs were found to be locally produced in thyroid cancer: IGF-I by stromal cells and IGF-II by malignant thyrocytes. Valueswere significantly higher in malignant tissue than in normal tissue. IGF-I-Rs were overexpressed in differentiated papillary carcinomas but not in poorly differentiated or undifferentiated tumours, whereas insulin receptors (IRs) were greatly overexpressed in all tumour hystotypes, with a trend forhigher values in dedifferentiated tumours. As at consequence of IR overexpression, high amounts of IR/IGF-I-R hybrids (which bind IGF-I with high affinity) were present in all thyroid cancer histotypes. Because of recent evidence that isoform A of IR (IR-A) is a physiological receptor for IGF-II infetal life, the relative abundance of IR-A in thyroid cancer was measured. Preliminary data indicate that overexpressed IRs mainly occur as IR-A in thyroid cancer. These data indicate that both IR/IGF-I-R hybrids and IR-A play an important role in the overactivation of the IGF system in thyroid cancer and in IGF-H mitogenic signalling in these tumours.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 21:39:18