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Titolo:
Frequent detection of the human herpesvirus 6-specific genomes in the livers of children with various liver diseases
Autore:
Ozaki, Y; Tajiri, H; Tanaka-Taya, K; Mushiake, S; Kimoto, A; Yamanishi, K; Okada, S;
Indirizzi:
Osaka Univ, Grad Sch Med, Dept Pediat, Suita, Osaka, Japan Osaka Univ Suita Osaka Japan d Sch Med, Dept Pediat, Suita, Osaka, Japan Osaka Univ, Grad Sch Med, Dept Microbiol, Suita, Osaka, Japan Osaka Univ Suita Osaka Japan ch Med, Dept Microbiol, Suita, Osaka, Japan Osaka Natl Hosp, Dept Pediat, Osaka, Japan Osaka Natl Hosp Osaka JapanOsaka Natl Hosp, Dept Pediat, Osaka, Japan Osaka Med Ctr, Dept Pathol, Osaka, Japan Osaka Med Ctr Osaka JapanOsaka Med Ctr, Dept Pathol, Osaka, Japan Res Inst Maternal & Child Hlth, Osaka, Japan Res Inst Maternal & Child Hlth Osaka Japan l & Child Hlth, Osaka, Japan
Titolo Testata:
JOURNAL OF CLINICAL MICROBIOLOGY
fascicolo: 6, volume: 39, anno: 2001,
pagine: 2173 - 2177
SICI:
0095-1137(200106)39:6<2173:FDOTHH>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
POLYMERASE CHAIN-REACTION; EXANTHEM-SUBITUM; FULMINANT-HEPATITIS; INFECTION; VIRUS; TRANSPLANTATION; ASSOCIATION; SYSTEM; INFANT; GENE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Tajiri, H Osaka Univ, Grad Sch Med, Dept Pediat, 2-2 Yamadaoka, Suita, Osaka, Japan Osaka Univ 2-2 Yamadaoka Suita Osaka Japan Suita, Osaka, Japan
Citazione:
Y. Ozaki et al., "Frequent detection of the human herpesvirus 6-specific genomes in the livers of children with various liver diseases", J CLIN MICR, 39(6), 2001, pp. 2173-2177

Abstract

This study was performed to investigate the frequency of human herpesvirus6 (HHV-6) infection of the liver in children with a variety of liver diseases and to evaluate the role of HHV-6 infection in pediatric patients with prolonged non-B non-C hepatitis. Detection of the HHV-6 genomes in liver, in peripheral blood mononuclear cells (PBMC), and in plasma was performed byPCR or by in situ hybridization, Liver biopsy materials from 48 patients, in whom HHV-6 infection was serologically confirmed, were available for PCRanalysis. Sequences of the HHV-6B genome were detectable in the livers of 36 of 48 patients (75%), The presence of the genome was not associated withserum transaminase activities. The genome was detectable in PBMC of 22 of 31 (71%) patients tested. In these 31 patients HHV-6 was detected in both the livers and PBMC of 20, was detected in PBMC but not in the livers of 2, was detected in the livers but not in PBMC of 3, and was detected in neither of samples of 6, In situ hybridization of the livers of six patients showed the presence of the HHV-6B genome in the nuclei of hepatocytes. The anti-HHV-6 immunoglobulin M antibody was detectable in 2 of 9 of the non-B non-C hepatitis patients, whereas none of the 22 patients with etiology-definedliver diseases tested positive. Cell-free viral DNA was not detectable in either group of patients. Our results showed that HHV-6B is frequently present in the livers of children with a variety of liver diseases but do not support the assumption that HHV-6B infection of the liver is associated withprolonged non-B non-C hepatitis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/07/20 alle ore 09:04:47