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Titolo:
The protease-activated receptor-2 agonist induces gastric mucus secretion and mucosal cytoprotection
Autore:
Kawabata, A; Kinoshita, M; Nishikawa, H; Kuroda, R; Nishida, M; Araki, H; Arizono, N; Oda, Y; Kakehi, K;
Indirizzi:
Kinki Univ, Fac Pharmaceut Sci, Dept Pathophysiol & Therapeut, Higashiosaka, Osaka 5778502, Japan Kinki Univ Higashiosaka Osaka Japan 5778502 hiosaka, Osaka 5778502, Japan Fuso Pharmaceut Ind Ltd, Ctr Res & Dev, Osaka, Japan Fuso Pharmaceut Ind Ltd Osaka Japan nd Ltd, Ctr Res & Dev, Osaka, Japan Kyoto Prefectural Univ Med, Dept Zool, Kyoto, Japan Kyoto Prefectural UnivMed Kyoto Japan niv Med, Dept Zool, Kyoto, Japan
Titolo Testata:
JOURNAL OF CLINICAL INVESTIGATION
fascicolo: 11, volume: 107, anno: 2001,
pagine: 1443 - 1450
SICI:
0021-9738(200106)107:11<1443:TPRAIG>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
BLOOD-FLOW RESPONSE; MAST-CELL TRYPTASE; (PAR(2))-ACTIVATING PEPTIDES; INTRAGASTRIC CAPSAICIN; MOLECULAR-CLONING; THROMBIN RECEPTOR; PAR-2; MUCIN; POTENT; MOUSE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Kawabata, A Kinki Univ, Fac Pharmaceut Sci, Dept Pathophysiol & Therapeut,3-4-1 Kowakae, Higashiosaka, Osaka 5778502, Japan Kinki Univ 3-4-1 KowakaeHigashiosaka Osaka Japan 5778502 apan
Citazione:
A. Kawabata et al., "The protease-activated receptor-2 agonist induces gastric mucus secretion and mucosal cytoprotection", J CLIN INV, 107(11), 2001, pp. 1443-1450

Abstract

Protease-activated receptor-2 (PAR-2), a receptor activated by trypsin/tryptase, modulates smooth muscle tone and exocrine secretion in the salivary glands and pancreas. Given that PAR-2 is expressed throughout the gastrointestinal tract, rye investigated effects of PAR-2 agonists on mucus secretion and gastric mucosal injury in the rat. PAR-2-activating peptides triggered secretion of mucus in the stomach, but not in the duodenum. This mucus secretion was abolished by pretreatment with capsaicin, which stimulates and ablates specific sensory neurons, but: it was resistant to cyclo-oxygenase inhibition. In contrast, capsaicin treatment failed to block PAR-2-mediatedsecretion from the salivary glands. Intravenous calcitonin gene-related peptide (CGRP) and neurokinin A markedly elicited gastric mucus secretion, asdid substance P to a lesser extent. Specific antagonists of the CGRP(1) and NK2, but not the NK1, receptors inhibited PAR-2-mediated mucus secretion. Pretreatment with the PAR-2 agonist strongly prevented gastric injury caused by HCl-ethanol or indomethacin. Thus, PAR-2 activation triggers the cytoprotective secretion of gastric mucus by stimulating the release of CGRP and tachykinins from sensory neurons. In contrast, the PAR-2-mediated salivary exocrine secretion appears to be independent of capsaicin-sensitive sensory neurons.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 12:44:13