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Titolo:
Immune responses against the myelin/oligodendrocyte glycoprotein in experimental autoimmune demyelination
Autore:
Von Budingen, HC; Tanuma, N; Villoslada, P; Ouallet, JC; Hauser, SL; Genain, CP;
Indirizzi:
Univ Calif San Francisco, Neuroimmunol Lab, Dept Neurol, San Francisco, CA94143 USA Univ Calif San Francisco San Francisco CA USA 94143 rancisco, CA94143 USA Univ Navarra, Dept Neurol, E-31080 Pamplona, Spain Univ Navarra PamplonaSpain E-31080 Dept Neurol, E-31080 Pamplona, Spain Hop Tenon, Dept Neurol, F-75970 Paris, France Hop Tenon Paris France F-75970 Tenon, Dept Neurol, F-75970 Paris, France
Titolo Testata:
JOURNAL OF CLINICAL IMMUNOLOGY
fascicolo: 3, volume: 21, anno: 2001,
pagine: 155 - 170
SICI:
0271-9142(200105)21:3<155:IRATMG>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
MYELIN-OLIGODENDROCYTE GLYCOPROTEIN; EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS; CENTRAL-NERVOUS-SYSTEM; MULTIPLE-SCLEROSIS PATHOLOGY; PROTEOLIPID PROTEIN GENE; ENCEPHALITOGENIC T-CELLS; MOG-INDUCED EAE; B-CELL; NONHUMAN PRIMATE; BASIC-PROTEIN;
Keywords:
autoimmunity; myelin proteins; epitopes; rodents; nonhuman primates;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
108
Recensione:
Indirizzi per estratti:
Indirizzo: Genain, CP Univ Calif San Francisco, Neuroimmunol Lab, Dept Neurol, Room C-440,505 Parnassus Ave, San Francisco, CA 94143 USA Univ Calif San Francisco Room C-440,505 Parnassus Ave San Francisco CA USA 94143
Citazione:
H.C. Von Budingen et al., "Immune responses against the myelin/oligodendrocyte glycoprotein in experimental autoimmune demyelination", J CLIN IMM, 21(3), 2001, pp. 155-170

Abstract

Myelin/oligodendrocyte glycoprotein (MOG) is a surface-exposed antigen of myelin and an important target for autoimmune responses which mediate inflammatory demyelination in the central nervous system. Experimentally, MOG induces strong pathogenic T cell responses in many strains of laboratory animals. Immunological studies in humans also identify MOG as a surprisingly prevalent antigenic molecule among the myelin proteins. In addition, the encephalitogenic properties of MOG are linked to the induction of antibody responses which have been demonstrated to directly promote central nervous system demyelination, a hallmark neuropathological feature in disorders such ashuman multiple sclerosis. Factors responsible for autoimmunity to MOG likely include genetic influences as well as other mechanisms, which are the subject of intense investigation. This article reviews experimental data currently available on specificity and pathogenic roles of T cell and antibody responses against MOG, which have implications relevant to multiple sclerosis and related disorders.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 01:22:38