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Titolo:
Dynamic enzymatic resolution of Naproxen methyl ester in a membrane bioreactor
Autore:
Xin, JY; Li, SB; Xu, Y; Chui, JR; Xia, CG;
Indirizzi:
Chinese Acad Sci, Lanzhou Inst Chem Phys, State Key Lab Oxo Synth & SelectOxidat, Lanzhou 730000, Peoples R China Chinese Acad Sci Lanzhou Peoples R China 730000 730000, Peoples R China
Titolo Testata:
JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY
fascicolo: 6, volume: 76, anno: 2001,
pagine: 579 - 585
SICI:
0268-2575(200106)76:6<579:DERONM>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
CANDIDA-RUGOSA LIPASE; ORGANIC-SOLVENTS; ENANTIOSELECTIVITY; ISOENZYMES; FORMS;
Keywords:
lipase; dynamic resolution; (S)-Naproxen; silicone rubber membrane; isoenzyme transformation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Engineering, Computing & Technology
Citazioni:
17
Recensione:
Indirizzi per estratti:
Indirizzo: Xin, JY Chinese Acad Sci, Lanzhou Inst Chem Phys, State Key Lab Oxo Synth & SelectOxidat, Lanzhou 730000, Peoples R China Chinese Acad Sci Lanzhou Peoples R China 730000 Peoples R China
Citazione:
J.Y. Xin et al., "Dynamic enzymatic resolution of Naproxen methyl ester in a membrane bioreactor", J CHEM TECH, 76(6), 2001, pp. 579-585

Abstract

A lipase-catalyzed enantioselective continuous hydrolysis process under insitu racemization of substrate using sodium hydroxide as catalyst was developed for the production of (S)-Naproxen from racemic Naproxen methyl esterin an aqueous-organic biphase system. Use of a tubular silicone rubber membrane in the stirred tank reactor to separate the chemical catalytic racemization and biocatalytic resolution processes, served to avoid the key problem associated with conventional dynamic resolution, viz the incompatibilityof in situ chemical racemization with the presence of a biocatalyst. To overcome product inhibition and to facilitate product recovery from the aqueous-organic emulsion containing substrate and lipase, a hydrophilic porous semipermeable membrane was used in the stirred tank reactor. Greater than 60% conversion of the racemate with an enantiomeric excess of product (ee(p))greater than 96% was obtained. In addition, transformation of Candida rugosa Lipase (CRL) isoenzymes was observed in the reaction process. (C) 2001 Society of Chemical Industry.

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Documento generato il 26/11/20 alle ore 11:21:36