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Titolo:
LC/MS confirmation of ionophores in animal feeds
Autore:
Turnipseed, SB; Roybal, JE; Pfenning, AP; Gonzales, SA; Hurlbut, JA; Madson, MR;
Indirizzi:
US FDA, Anim Drugs Res Ctr, Denver, CO 80225 USA US FDA Denver CO USA 80225 FDA, Anim Drugs Res Ctr, Denver, CO 80225 USA Denver Dist Lab, Denver, CO 80225 USA Denver Dist Lab Denver CO USA 80225Denver Dist Lab, Denver, CO 80225 USA
Titolo Testata:
JOURNAL OF AOAC INTERNATIONAL
fascicolo: 3, volume: 84, anno: 2001,
pagine: 640 - 647
SICI:
1060-3271(200105/06)84:3<640:LCOIIA>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
LIQUID-CHROMATOGRAPHIC DETERMINATION; ELECTROSPRAY MASS-SPECTROMETRY; COLLISION-INDUCED DISSOCIATION; MONENSIN; SALINOMYCIN; NARASIN; IONIZATION; EGGS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Citazioni:
15
Recensione:
Indirizzi per estratti:
Indirizzo: Turnipseed, SB US FDA, Anim Drugs Res Ctr, Denver, CO 80225 USA US FDA Denver CO USA 80225 s Res Ctr, Denver, CO 80225 USA
Citazione:
S.B. Turnipseed et al., "LC/MS confirmation of ionophores in animal feeds", J AOAC INT, 84(3), 2001, pp. 640-647

Abstract

A liquid chromatographic/mass spectrometric (LC/MS) electrospray confirmation method has been developed to confirm 4 ionophores (monensin, lasalocid,salinomycin, and narasin) in a variety of animal feeds using a single quadrupole mass spectrometer, The sodium ions of these compounds are dominant in the electrospray mass spectrum, Using optimized "in-source" collision induced dissociation, characteristic fragment ions seen previously using MS/MScan be observed. The drugs were extracted from the feed matrix using hexane-ethyl acetate and isolated using a silica solid-phase extraction cartridge. These ionophores were confirmed in both medicated feeds and nonmedicatedfeeds fortified with these drugs at the 1-50 ppm level. In addition, this method was used to confirm residues of monensin in a nonmedicated feed thatwas collected from a feed mill immediately after the production of a similar feed that was medicated with high levels of monensin.

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Documento generato il 02/07/20 alle ore 16:42:00