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Titolo:
Cytokines in bone and cartilage destruction and repair
Autore:
van den Berg, W;
Indirizzi:
Univ Nijmegen, Med Ctr, Rheumatol Res Lab, Nijmegen, Netherlands Univ Nijmegen Nijmegen Netherlands matol Res Lab, Nijmegen, Netherlands
Titolo Testata:
JCR-JOURNAL OF CLINICAL RHEUMATOLOGY
fascicolo: 3, volume: 7, anno: 2001, supplemento:, S
pagine: S8 - S11
SICI:
1076-1608(200106)7:3<S8:CIBACD>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
COLLAGEN-INDUCED ARTHRITIS; OSTEOPROTEGERIN LIGAND; RHEUMATOID-ARTHRITIS; METALLOPROTEINASE; MICE; EXPRESSION; REGULATOR; EROSIONS; ALPHA; GENE;
Keywords:
cytokines; IL-1; TNF; joint erosion; arthritis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: van den Berg, W Univ Nijmegen, Med Ctr, Rheumatol Res Lab, Nijmegen, Netherlands Univ Nijmegen Nijmegen Netherlands ijmegen, Netherlands
Citazione:
W. van den Berg, "Cytokines in bone and cartilage destruction and repair", JCR-J CLIN, 7(3), 2001, pp. S8-S11

Abstract

It is widely recognized that tumor necrosis factor (TNF) is a major targetin developing therapy for rheumatoid arthritis (RA). Many trials are in progress that are expected to show a benefit from blocking the production or inhibiting the activity of this cytokine. Nevertheless, studies using a variety of animal models suggest that, although TNF is the key cytokine mediating joint swelling, it plays no direct role in tissue destruction. Conversely, interleukin-1 (IL-1) does not play a significant role in the early inflammation process but plays a pivotal role in erosive cartilage damage. The mechanisms of cartilage destruction are described, with particular attention given to the distinct roles of TNF and IL-1. It is concluded that IL-1 beta may be an equally important or even more important target, and outcomes in RA might be improved by therapies that address both of those cytokines.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 22:23:59