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Titolo:
Role of proinflammatory cytokine inhibition in rheumatoid arthritis
Autore:
Dayer, JM;
Indirizzi:
Univ Hosp Geneva, Div Immunol & Allergy, Geneva, Switzerland Univ Hosp Geneva Geneva Switzerland unol & Allergy, Geneva, Switzerland
Titolo Testata:
JCR-JOURNAL OF CLINICAL RHEUMATOLOGY
fascicolo: 3, volume: 7, anno: 2001, supplemento:, S
pagine: S3 - S7
SICI:
1076-1608(200106)7:3<S3:ROPCII>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
NECROSIS-FACTOR-ALPHA; COLLAGEN-INDUCED ARTHRITIS; FACTOR-BINDING-PROTEIN; HUMAN SYNOVIAL-CELLS; STIMULATES COLLAGENASE; GLYCOSAMINOGLYCAN SYNTHESIS; RECEPTOR ANTAGONIST; BONE-RESORPTION; TNF RECEPTOR; T-CELLS;
Keywords:
rheumatoid arthritis; interleukin-1 (IL-1); interleukin-1 receptor antagonist (IL-1Ra); tumor necrosis factor (TNF); cell-cell contact; apolipoprotein A-I (APoA-I);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Dayer, JM Univ Hosp Geneva, Div Immunol & Allergy, Geneva, Switzerland Univ Hosp Geneva Geneva Switzerland ergy, Geneva, Switzerland
Citazione:
J.M. Dayer, "Role of proinflammatory cytokine inhibition in rheumatoid arthritis", JCR-J CLIN, 7(3), 2001, pp. S3-S7

Abstract

Cytokines play a major role in the pathologic processes of rheumatoid arthritis (RA). In response to one or more triggers yet unknown, the productionof various cytokines by infiltrating and resident cells escapes regulatorymechanisms and causes inflammation, pain, and tissue destruction. Current data indicate that tumor necrosis factor alpha (TNF-alpha) and interleukin-1 (IL-1) are the key mediators of inflammation and the destructive process. In addition, IL-1, either as membrane-bound IL-1 alpha or secreted IL-1 beta, inhibits the tissue repair process. Inhibiting the production, release,and/or action of these proinflammatory and prodestructive cytokines may beof benefit in the sustained treatment of chronic destructive disease. Based on in vivo data, animal experimental models, and clinical trials, blocking the biological activity of TNF-alpha by soluble receptors (TNF-sR) or antibodies to TNF-alpha as well as the development of molecules that specifically bind to membrane receptors such as IL-1 receptor antagonist (IL-1Ra), are very promising approaches. This article discusses the inflammatory and destructive processes and describes the basic concept for treating RA. by inhibiting the offending cytokines, particularly IL-1 and TNF-or. Furthermore, a new approach that consists of interfering in the production:of both TNF-alpha and IL-1 on monocyte-macrophages during their contact with stimulated T helper type 1 (Th1) lymphocytes will be discussed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 12:28:10