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Titolo:
Frequency dependence of local cerebral blood flow induced by somatosensoryhind paw stimulation in rat under normo- and hypercapnia
Autore:
Bakalova, R; Matsuura, T; Kanno, I;
Indirizzi:
Akita Res Inst Brain & Blood Vessels, Dept Radiol & Nucl Med, Akita 0100874, Japan Akita Res Inst Brain & Blood Vessels Akita Japan 0100874 0100874, Japan Japan Sci & Technol Corp, Akita Res Inst Brain & Blood Vessels, Akita Lab,Akita 0100874, Japan Japan Sci & Technol Corp Akita Japan 0100874 ta Lab,Akita 0100874, Japan
Titolo Testata:
JAPANESE JOURNAL OF PHYSIOLOGY
fascicolo: 2, volume: 51, anno: 2001,
pagine: 201 - 208
SICI:
0021-521X(200104)51:2<201:FDOLCB>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
LASER-DOPPLER MEASUREMENTS; NITRIC-OXIDE SYNTHASE; BRAIN; CORTEX; ACTIVATION; METABOLISM; CBF; CIRCULATION; POTASSIUM; INCREASES;
Keywords:
cerebral blood flow; hind paw stimulation; hypercapnia; somatosensory cortex; laser-Doppler flowmetry;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Matsuura, T Akita Res Inst Brain & Blood Vessels, Dept Radiol & Nucl Med, 6-10 Senshukubota Machi, Akita 0100874, Japan Akita Res Inst Brain & Blood Vessels 6-10 Senshukubota Machi Akita Japan 0100874
Citazione:
R. Bakalova et al., "Frequency dependence of local cerebral blood flow induced by somatosensoryhind paw stimulation in rat under normo- and hypercapnia", JPN J PHYSL, 51(2), 2001, pp. 201-208

Abstract

We measured the field potential and the changes in local cerebral blood flow (LCBF) response during somatosensory activation (evoked LCBF) in alpha -chloralose-anesthetized rats by laser-Doppler flowmetry under normocapnia (PaCO2=34.3 +/-3.8 mmHg) and hypercapnia (PaCO2=70.1 +/-9.8 mmHg). Somatosensory activation was induced by electrical stimulation (0.2, 1, and 5 Hz with 1.5 mA for 5 s) of the hind paw. The neuronal activity of the somatosensory area of the hind paw was linear to the stimulus frequency, and there wasno significant difference in the neuronal activity between hypercapnia andnormocapnia. The baseline level of LCBF under hypercapnia was about 72.2% higher than that under normocapnia (p <0.01). The absolute response magnitude under hypercapnia was greater than that under normocapnia (p <0.05). Theevoked LCBF under both conditions showed a frequency-dependent increase inthe 0.2 to 5 Hz range, and the difference in the absolute response magnitude at the same stimulus frequency between normocapnia and hypercapnia became large with increasing stimulus frequency (p <0.05). On the other hand, after normalization to each baseline level there was no significant difference in the response magnitude of the normalized evoked LCBF between normocapnia and hypercapnia, indicating that the normalized evoked LCBF reflects neuronal activity even when the baseline LCBF was changed by the PaCO2 level. The peak time and termination time of LCBF response curves with respect to the graded neuronal activity at 1 and 5 Hz stimulation increased significantly under hypercapnia, compared with those under normocapnia (p <0.05), although the rise time of 0.5 s was nearly constant. In conclusion, the results suggest a synergistic effect of the combined application of graded neuronal stimuli and hypercapnia on the LCBF response.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/09/20 alle ore 01:05:01