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Titolo:
A moderate elevation of blood glucose level increases the effectiveness ofthermoradiotherapy in a rat tumor model ii. improved tumor control at clinically achievable temperatures
Autore:
van den Berg, AP; van den Berg-Blok, AE; Kal, HB; Reinhold, HS;
Indirizzi:
Univ Hosp Rotterdam Daniel, Dept Radiat Oncol, Rotterdam, Netherlands UnivHosp Rotterdam Daniel Rotterdam Netherlands Rotterdam, Netherlands Erasmus Univ, Rotterdam, Netherlands Erasmus Univ Rotterdam NetherlandsErasmus Univ, Rotterdam, Netherlands TNO, Inst Radiobiol, Rijswijk, Netherlands TNO Rijswijk NetherlandsTNO, Inst Radiobiol, Rijswijk, Netherlands Univ Utrecht, Ctr Med, Dept Radiotherapy, Utrecht, Netherlands Univ Utrecht Utrecht Netherlands ept Radiotherapy, Utrecht, Netherlands
Titolo Testata:
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
fascicolo: 3, volume: 50, anno: 2001,
pagine: 793 - 801
SICI:
0360-3016(20010701)50:3<793:AMEOBG>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
LOW EXTRACELLULAR PH; INTRACELLULAR-PH; HYPOXIC FRACTION; PROTON EXTRUSION; HYPERTHERMIA; CELLS; RADIATION; HYPERGLYCEMIA; OXYGENATION; IRRADIATION;
Keywords:
tumor pH; glucose; hyperthermia; radiation; thermoradiotherapy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
53
Recensione:
Indirizzi per estratti:
Indirizzo: van den Berg, AP Josephine Nefkens Inst, Radiobiol Sect, POB 1738, NL-3000DR Rotterdam, Netherlands Josephine Nefkens Inst POB 1738 Rotterdam Netherlands NL-3000 DR
Citazione:
A.P. van den Berg et al., "A moderate elevation of blood glucose level increases the effectiveness ofthermoradiotherapy in a rat tumor model ii. improved tumor control at clinically achievable temperatures", INT J RAD O, 50(3), 2001, pp. 793-801

Abstract

Purpose: To assess the therapeutic gain (at the TCD50 level) that can be obtained by boosting thermoradiotherapy with intravenous glucose infusion atdifferent temperatures. This completes our series of studies to determine the optimal conditions and the effectiveness of glucose administration at clinically achievable glucose levels and treatment temperatures. Methods andMaterials: Subcutaneous rat rhabdomyosarcoma BA1112 was irradiated with graded single doses of 300-kV X-rays (dose range 0-60 Gy), Fifteen minutes after irradiation, a 100-min intravenous infusion was started, consisting of either glucose (20% solution, 2.4-3 g/kg/h) or saline as a control. Then heat was applied to the tumors at 42 degreesC or 43 degreesC (water bath) during a subsequent 100-min period of infusion. Tumor control was scored as the absence of palpable growth at 100 days after treatment. Results: Glucose infusion enhanced tumor control independent of temperature in the range 42-43 degreesC. At 42 degreesC, the TCD50 for X-irradiation decreased by 5.9 Gy (SEM 1.8 Gy), from 41.6 (1.6) to 35.7 (1.5) Gy, and at 43 degreesC from 33.3 (1.6) to 27.3 (1.5) Gy, representing a glucose enhancement ratio of approximately 1,2, At doses corresponding to the TCD50 at either 42 or 43 degreesC, the addition of glucose increased tumor control from 50% to 70%. An enhancement ratio of 2.1 was found for the combination of irradiation, glucose infusion, and heating at 43 degreesC, with respect to irradiation alone (TCD50 56.3 Gy, reanalyzed earlier data). The contribution of combined heatand glucose to tumor control represented an additive effect, probably on the hypoxic cell population. Conclusion: Moderate glucose administration (blood concentration 300 mg/100 mt) sizably improves experimental tumor control after combined X-irradiation and hyperthermia under clinically feasible conditions. Clinical treatment should benefit from this additional modality,in particular if unsatisfactory local control rates are due to insufficient heating. The therapeutic gain has to be evaluated further in clinical studies. (C) 2001 Elsevier Science Inc.

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Documento generato il 03/06/20 alle ore 23:08:24