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Titolo:
Level of Flt3-ligand in plasma: a possible new bio-indicator for radiation-induced aplasia
Autore:
Bertho, JM; Demarquay, C; Frick, J; Joubert, C; Arenales, S; Jacquet, N; Sorokine-Durm, I; Chau, Q; Lopez, M; Aigueperse, J; Gorin, NC; Gourmelon, P;
Indirizzi:
Inst Protect & Surete Nucl, Dept Protect Sante Homme & Dosimetrie, Sect Autonome Radiobiol Appl Med, F-92265 Fontenay Aux Roses, France Inst Protect & Surete Nucl Fontenay Aux Roses France F-92265 ses, France Inst Protect & Surete Nucl, Lab Dosimetrie Biol Multiparametr, F-92265 Fontenay Aux Roses, France Inst Protect & Surete Nucl Fontenay Aux Roses France F-92265 ses, France Inst Protect & Surete Nucl, Serv Dosimetrie, F-92265 Fontenay Aux Roses, France Inst Protect & Surete Nucl Fontenay Aux Roses France F-92265 ses, France CHU St Antoine, Lab Therapie Cellulaire & Radioprotect Accidentel, Paris, France CHU St Antoine Paris France re & Radioprotect Accidentel, Paris, France Hop St Antoine, Serv Malad Sang, F-75571 Paris, France Hop St Antoine Paris France F-75571 rv Malad Sang, F-75571 Paris, France CHU St Antoine, INSERM, U76, Paris, France CHU St Antoine Paris FranceCHU St Antoine, INSERM, U76, Paris, France
Titolo Testata:
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
fascicolo: 6, volume: 77, anno: 2001,
pagine: 703 - 712
SICI:
0955-3002(200106)77:6<703:LOFIPA>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
TOTAL-BODY IRRADIATION; FLT3 LIGAND; PROGENITOR CELLS; GROWTH; EXPRESSION; EXPOSURE; DIFFERENTIATION; HEMATOPOIESIS; MECHANISM; ACCIDENTS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Bertho, JM Inst Protect & Surete Nucl, Dept Protect Sante Homme & Dosimetrie, Sect Autonome Radiobiol Appl Med, Rue Auguste Lemaire,BP6, F-92265 Fontenay Aux Roses, France Inst Protect & Surete Nucl Rue Auguste Lemaire,BP6 Fontenay Aux Roses France F-92265
Citazione:
J.M. Bertho et al., "Level of Flt3-ligand in plasma: a possible new bio-indicator for radiation-induced aplasia", INT J RAD B, 77(6), 2001, pp. 703-712

Abstract

Purpose: To follow plasma Flt3-ligand (FL) concentrations in irradiated animals in order to evaluate it as an indicator of bone marrow damage for themanagement of accidental radiation-induced aplasia. Materials and methods: Non-human primates were irradiated at doses rangingfrom 2 to 8 Gy, using whole- or partial-body irradiation. Plasma FL concentrations and blood cell counts were determined daily. Results: FL concentrations increased as early as day 2 after irradiation, whatever the irradiation dose. Increase in plasma FL concentration on day 5post-irradiation was correlated with radiation dose and with the severity of radiation-induced aplasia. During the course of aplasia, FL concentrations in plasma were inversely correlated with neutrophil counts. A peak in FLconcentration appeared before the neutrophil nadir, and the subsequent decrease in FL concentration was correlated with the recovery of blood-cell populations. Conclusions : Monitoring plasma FL concentration can be used as an indicator of radiation-induced marrow aplasia, and this may be of use in accidental irradiation situations.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/09/20 alle ore 20:42:15