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Titolo:
Polymorphisms in the insulin response element of APOC-III gene promoter influence the correlation between insulin and triglycerides or triglyceride-rich lipoproteins in humans
Autore:
Dallongeville, J; Meirhaeghe, A; Cottel, D; Fruchart, JC; Amouyel, P; Helbecque, N;
Indirizzi:
Inst Pasteur, Serv Epidemiol & Sante Publ, F-59019 Lille, France Inst Pasteur Lille France F-59019 ol & Sante Publ, F-59019 Lille, France Inst Pasteur, INSERM U508, F-59019 Lille, France Inst Pasteur Lille France F-59019 ur, INSERM U508, F-59019 Lille, France Inst Pasteur, Dept Atherosclerose, F-59019 Lille, France Inst Pasteur Lille France F-59019 Atherosclerose, F-59019 Lille, France Inst Pasteur, F-59019 Lille, France Inst Pasteur Lille France F-59019Inst Pasteur, F-59019 Lille, France INSERM U325, Lille, France INSERM U325 Lille FranceINSERM U325, Lille, France
Titolo Testata:
INTERNATIONAL JOURNAL OF OBESITY
fascicolo: 7, volume: 25, anno: 2001,
pagine: 1012 - 1017
SICI:
0307-0565(200107)25:7<1012:PITIRE>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
APOLIPOPROTEIN-C-III; PLASMA-LIPOPROTEINS; MYOCARDIAL-INFARCTION; TRANSGENIC MICE; CIII; HYPERTRIGLYCERIDEMIA; ASSOCIATION; RECEPTOR; CLUSTER; SAMPLE;
Keywords:
triglycerides; apoC-III; insulin; lipoproteins;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Dallongeville, J Inst Pasteur, Serv Epidemiol & Sante Publ, 1 Rue Professeur Calmette, F-59019 Lille, France Inst Pasteur 1 Rue Professeur Calmette Lille France F-59019
Citazione:
J. Dallongeville et al., "Polymorphisms in the insulin response element of APOC-III gene promoter influence the correlation between insulin and triglycerides or triglyceride-rich lipoproteins in humans", INT J OBES, 25(7), 2001, pp. 1012-1017

Abstract

OBJECTIVE: To assess whether the -455 and -482 mutations in APOC-III gene insulin response element affect the relationships between plasma insulin and triglyceride-rich lipoprotein levels. DESIGN: Population-based studies. SUBJECTS: The population sample was composed of 983 subjects (485 men and 498 women), aged between 35 and 65y, randomly sampled from the electoral rolls in Northern France and stratified on gender and 10y age groups. MEASUREMENTS: Plasma triglyceride, apolipoprotein C-III, apoB, LpC-III:B and LpE:B lipoprotein particles and insulin levels were measured. Two polymorphisms in APOC-III gene insulin response element (T -->C at -455 and/or C -->T at -482) were determined. RESULTS: Plasma insulin was positively correlated to triglyceride levels (P < 0.0001), apo C-III (P < 0.003), LpC-III:B (P < 0.0001), apoB (P < 0.0001) and LpE:B (P < .0001). This association differed significantly accordingto APOC-III insulin response element polymorphisms. The relationship between insulin and LpC-III:B (P < 0.02) or apoB (P < 0.02) was greater in womenbearing the C allele of -455 than the T allele. Similarly, the relationship between insulin and LpC-III:B (P < 0.02) or LpE:B (P < 0.05) was greater in women bearing the T allele of -482 than the C allele. There was no evidence for any effect in men. CONCLUSION: These results suggest that the relationship between plasma insulin and triglyceride-rich lipoprotein levels is partly influenced by polymorphisms in APOC-III insulin response element.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 06:22:09