Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
The anorectic effect of a chronic peripheral infusion of amylin is abolished in area postrema nucleus of the solitary tract (AP/NTS) lesioned rats
Autore:
Lutz, TA; Mollet, A; Rushing, PA; Riediger, T; Scharrer, E;
Indirizzi:
Univ Zurich, Inst Vet Physiol, CH-8057 Zurich, Switzerland Univ Zurich Zurich Switzerland CH-8057 siol, CH-8057 Zurich, Switzerland Univ Cincinnati, Dept Psychiat, Cincinnati, OH USA Univ Cincinnati Cincinnati OH USA ati, Dept Psychiat, Cincinnati, OH USA
Titolo Testata:
INTERNATIONAL JOURNAL OF OBESITY
fascicolo: 7, volume: 25, anno: 2001,
pagine: 1005 - 1011
SICI:
0307-0565(200107)25:7<1005:TAEOAC>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
FOOD-INTAKE; INSULIN-SECRETION; PEPTIDE CGRP; BRAIN;
Keywords:
amylin; salmon calcitonin; area postrema; nucleus of the solitary tract; food intake; chronic infusion; rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Lutz, TA Univ Zurich, Inst Vet Physiol, Winterthurerstr 260, CH-8057 Zurich, Switzerland Univ Zurich Winterthurerstr 260 Zurich Switzerland CH-8057 rland
Citazione:
T.A. Lutz et al., "The anorectic effect of a chronic peripheral infusion of amylin is abolished in area postrema nucleus of the solitary tract (AP/NTS) lesioned rats", INT J OBES, 25(7), 2001, pp. 1005-1011

Abstract

OBJECTIVE: Neurons in the area postrema/nucleus of the solitary tract (AP/NTS) region mediate amylin's anorectic effect elicited by a single intraperitoneal (i.p.) injection of a low dose (5 mug/kg). Here, we tested if a sustained elevation in amylin levels which was achieved by chronic amylin infusion reduces food intake by acting in the AP/NTS region or, possibly, at other brain sites. Further, we tested the role of the AP/NTS region in mediating the anorectic effects of high doses of amylin and its receptor agonist salmon calcitonin (sCT) after an acute single injection. DESIGN: Amylin (2 mug/kg/h) was chronically infused i.p. by osmotic minipumps in AP/NTS-lesioned (AP-X) or sham-lesioned (SHAM) rats. For the acute experiments, amylin or sCT was injected i.p. at doses of 0.5 (only sCT), 5 or 50 mug/kg. Food intake was measured by a computerized system. Body weightwas assessed by manually weighing the rats. RESULTS: Amylin significantly reduced cumulative food intake for about 7 days in SHAM but not in AP-X rats. Amylin's effect in SHAM rats was mainly due to a reduction of the size of nocturnal meals (eg average meal size during the first four dark phases; SHAM, NaCl 4.1 +/- 0.6 vs amylin 2.6 +/- 0.4g; n=6, P < 0.05; AP-X, 2.6 <plus/minus> 0.3 vs 3.7 +/- 0.3) while light phase food intake was unaffected. Body weight gain over the whole 14 day infusion period was reduced by amylin in SHAM (NaCl 61 +/- 6 vs amylin 46 +/- 4 g; P < 0.05) but not in AP-X rats (54 <plus/minus> 4 vs 62 +/- 4). After single injection, the anorectic effect of high doses of amylin and sCT (50 mug/kg) was attenuated, but not abolished, in AP-X rats. CONCLUSION: We conclude that, under our experimental conditions, neurons in the AP/NTS region are necessary for chronically elevated peripheral amylin to reduce food intake in rats. High doses of amylin, however, may be ableto overrun these receptors and reduce feeding by acting at other brain sites.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 00:20:30