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Titolo:
NMDA receptor-mediated modulation of ventilation in obese Zucker rats
Autore:
Lee, SD; Nakano, H; Farkas, GA;
Indirizzi:
SUNY Buffalo, Dept Phys Therapy Exercise & Nutr Sci, Buffalo, NY 14214 USASUNY Buffalo Buffalo NY USA 14214 rcise & Nutr Sci, Buffalo, NY 14214 USA
Titolo Testata:
INTERNATIONAL JOURNAL OF OBESITY
fascicolo: 7, volume: 25, anno: 2001,
pagine: 997 - 1004
SICI:
0307-0565(200107)25:7<997:NRMOVI>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
NUCLEUS-TRACTUS-SOLITARII; ACID NEUROTRANSMITTERS; HYPOXIA; DEXTROMETHORPHAN; PHARMACOKINETICS; DEXTRORPHAN; GLUTAMATE;
Keywords:
respiration; N-methyl-D-aspartate; dextromethorphan;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Farkas, GA SUNY Buffalo, Dept Phys Therapy Exercise & Nutr Sci, 405 Kimball Tower,3435 Main St, Buffalo, NY 14214 USA SUNY Buffalo 405 Kimball Tower,3435 Main St Buffalo NY USA 14214
Citazione:
S.D. Lee et al., "NMDA receptor-mediated modulation of ventilation in obese Zucker rats", INT J OBES, 25(7), 2001, pp. 997-1004

Abstract

BACKGROUND: Ventilation in response to hypoxia is reduced in some obese humans and is believed to represent part of the pathogenesis of obesity hypoventilation syndrome (OHS). Ventilation in response to hypoxic exposure is closely related to the release of excitatory neurotransmitters, in particular glutamate, acting specifically on N-methyl-D-aspartate (NMDA) receptors. OBJECTIVES: The aim of the present study was to investigate whether NMDA receptor-mediated mechanisms are responsible for the altered ventilatory response to sustained hypoxia observed in obese Zucker (Z) rats. SUBJECTS: Seven lean and seven 15-week-old obese male Z rats were studied. MEASUREMENTS: Ventilation (V-E) at rest and during 30 min sustained hypoxic (10% O-2) exposure was measured by the barometric method, V-E was assessed following the blinded-random administration of equal volumes of either saline (vehicle) or dextromethorphan (DM, 10 mg/kg), a non-competitive glutamate NMDA receptor antagonist. RESULTS: DM had no effects on resting V-E in both lean and obese rats during room air breathing. Lean rats treated with DM exhibited a significant (P< 0.05) depression in V-E, V-T, and V-T/T-1 during either the early (5 min) or the late phase (30 min) of ventilatory response to sustained hypoxia. In contrast, DM administration in obese rats did not change Ve VT, Or V-T/T-1 during the early phase of ventilatory response to hypoxia. During the late phase of ventilatory response to hypoxia. obese rats treated with DM exhibited a similar depression in V-E and V-T as observed in lean rats, but had no significant change in V-T/T-1 during the 30 min hypoxic exposure. CONCLUSION: Our findings indicate that altered glutamatergic mechanisms acting on NMDA receptors are partially responsible for a blunted early phase of ventilatory response to hypoxia noted in obese rats and also contribute to their reduced neural respiratory drive.

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Documento generato il 23/09/20 alle ore 13:12:41