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Titolo:
Primary immune system effects of the orally administered cyclopentane neuraminidase inhibitor RWJ-270201 in influenza virus-infected mice
Autore:
Sidwell, RW; Smee, DF; Bailey, KW; Burger, RA;
Indirizzi:
Utah State Univ, Inst Antiviral Res, Logan, UT 84322 USA Utah State Univ Logan UT USA 84322 nst Antiviral Res, Logan, UT 84322 USA Miltenyi Biotech, Auburn, CA 95603 USA Miltenyi Biotech Auburn CA USA 95603 ltenyi Biotech, Auburn, CA 95603 USA
Titolo Testata:
INTERNATIONAL IMMUNOPHARMACOLOGY
fascicolo: 6, volume: 1, anno: 2001,
pagine: 1211 - 1218
SICI:
1567-5769(200106)1:6<1211:PISEOT>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
NATURAL-KILLER-CELLS; T-CELLS; A VIRUS; LYMPHOCYTES;
Keywords:
influenza; RWJ-270201; neuraminidase inhibitor; natural killer cell; cytotoxic T cell; macrophage; antiviral;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Sidwell, RW Utah State Univ, Inst Antiviral Res, 5600 Old Main Hill, Logan, UT 84322 USA Utah State Univ 5600 Old Main Hill Logan UT USA 84322 4322 USA
Citazione:
R.W. Sidwell et al., "Primary immune system effects of the orally administered cyclopentane neuraminidase inhibitor RWJ-270201 in influenza virus-infected mice", INT IMMUNO, 1(6), 2001, pp. 1211-1218

Abstract

The cyclopentane derivative [1S,2S,3R,4R]-3-[(1S)-1 -(acetylamino)-2-ethylbutyl]-4-[(aminomethyl)amino]-2-hydroxy-cyclopentanecarboxylic acid (RWJ-270201) has been previously reported to be a potent and selective inhibitor of influenza virus neuraminidase, and to inhibit infections with this virus in vitro, in mice, and in clinical challenge studies. The effect of oral gavage therapy of 100 mg/kg/day of RWJ-2710201 administered twice daily for 5days beginning 16 h prior to virus exposure, on various immune factors of importance in response to primary influenza infection was determined in mice infected with influenza A/Shangdong/09/93 (H3N2) virus. Spleens taken from the mice 2 h after termination of treatment were processed for cytotoxic T lymphocytes (CTL) and natural killer (NK) cell activity and for enumeration of macrophages, T, T-helper, T-suppressor/cytotoxic, and B cells. Saline-treated mice and normal mice were run in parallel. Treatment had no significant effect on any immune parameter. In a second experiment, mice infectedwith influenza A/NWS/33 (H1N1) were treated similarly with RWJ-270201 beginning 4 h pre-virus exposure. Treatment prevented any deaths from occurring, and markedly lessened arterial oxygen decline, lung consolidation, and lung virus titers. The mice developed mean neutralizing antibody (NA) titers of 1:592, and six of seven rechallenged mice resisted rechallenge with the same virus, indicating the initial virus-inhibitory effect also did not prevent the animals from developing an adequate humoral immune response to thevirus. (C) 2001 Elsevier Science :B.V. All rights reserved.

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Documento generato il 31/03/20 alle ore 15:34:11