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Titolo:
Effects of Linomide on immune cells and cytokines inhibit autoimmune pathologies of the central and peripheral nervous system
Autore:
Hedlund, G; Link, H; Zhu, J; Xiao, BG;
Indirizzi:
Huddinge Univ Hosp, Karolinska Inst, Div Neurol, Neuroimmunol Unit, Stockholm, Sweden Huddinge Univ Hosp Stockholm Sweden euroimmunol Unit, Stockholm, Sweden Huddinge Univ Hosp, Karolinska Inst, Div Neurol, Expt Neurol Unit, Stockholm, Sweden Huddinge Univ Hosp Stockholm Sweden Expt Neurol Unit, Stockholm, Sweden Act Biotech Res AB, S-22007 Lund, Sweden Act Biotech Res AB Lund Sweden S-22007 tech Res AB, S-22007 Lund, Sweden Huddinge Univ Hosp, Karolinska Inst, Div Geriatr Med, Stockholm, Sweden Huddinge Univ Hosp Stockholm Sweden Div Geriatr Med, Stockholm, Sweden
Titolo Testata:
INTERNATIONAL IMMUNOPHARMACOLOGY
fascicolo: 6, volume: 1, anno: 2001,
pagine: 1123 - 1130
SICI:
1567-5769(200106)1:6<1123:EOLOIC>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
SYNTHETIC IMMUNOMODULATOR LINOMIDE; EXPERIMENTAL ALLERGIC NEURITIS; DELAYED-TYPE HYPERSENSITIVITY; SECONDARY PROGRESSIVE MS; MYASTHENIA-GRAVIS; MULTIPLE-SCLEROSIS; GAMMA-INTERFERON; T-CELLS; LEWIS RATS; IN-VIVO;
Keywords:
Linomide; cytokines; nervous system;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
65
Recensione:
Indirizzi per estratti:
Indirizzo: Link, H Huddinge Univ Hosp, Karolinska Inst, Div Neurol, Neuroimmunol Unit, Stockholm, Sweden Huddinge Univ Hosp Stockholm Sweden nol Unit, Stockholm, Sweden
Citazione:
G. Hedlund et al., "Effects of Linomide on immune cells and cytokines inhibit autoimmune pathologies of the central and peripheral nervous system", INT IMMUNO, 1(6), 2001, pp. 1123-1130

Abstract

Linomide (roquinimex, LS 2616) is a quinoline-3-carboxamide with pleiotropic immune modulating capacity and it has therapeutic effects in several experimental animal models of autoimmune diseases; Linomide has been evaluatedin clinical trials for multiple sclerosis, and was indeed shown to have disease inhibitory effects. However, due to unexpected side effects recorded in patients treated with Linomide, premature termination of clinical trialswas required. The basic mechanism(s) of action of Linomide in inducing beneficial effects in autoimmune diseases is still elusive. Some experimental evidence indicates that Linomide influences the regulation of the cytokine profile, resulting in the inhibition of autoimmune and inflammation pathologies. This review focuses on Linomide applied in models for autoimmune and inflammation pathologies of the central and the peripheral nervous system, and summarises its very encouraging disease inhibitory effects and their potential pharmacological basis. The beneficial effects recorded with Linomide in both experimental and clinical trials emphasise the possible value of substances with Linomide-like activity for clinical use in autoimmune and inflammation pathologies in the near future. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 12:39:00