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Titolo:
A role for parathyroid hormone-related protein in the pathogenesis of inflammatory/autoimmune diseases
Autore:
Funk, JL;
Indirizzi:
Univ Arizona, Dept Med, Tucson, AZ USA Univ Arizona Tucson AZ USAUniv Arizona, Dept Med, Tucson, AZ USA
Titolo Testata:
INTERNATIONAL IMMUNOPHARMACOLOGY
fascicolo: 6, volume: 1, anno: 2001,
pagine: 1101 - 1121
SICI:
1567-5769(200106)1:6<1101:ARFPHP>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; CYTOKINE GENE-EXPRESSION; ACUTE-PHASE RESPONSE; INTERLEUKIN-1 RECEPTOR ANTAGONIST; MESSENGER-RIBONUCLEIC-ACID; DEVELOPMENTAL REGULATORY MOLECULE; CARTILAGE PANNUS JUNCTION; RHEUMATOID SYNOVIAL-CELLS; COLONY-STIMULATING FACTOR; SMOOTH-MUSCLE CELLS;
Keywords:
PTHrP; TNF-alpha; endotoxin; rheumatoid arthritis;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
133
Recensione:
Indirizzi per estratti:
Indirizzo: Funk, JL Arizona Hlth Sci Ctr, Box 24-5021, Tucson, AZ 85724 USA Arizona Hlth Sci Ctr Box 24-5021 Tucson AZ USA 85724 AZ 85724 USA
Citazione:
J.L. Funk, "A role for parathyroid hormone-related protein in the pathogenesis of inflammatory/autoimmune diseases", INT IMMUNO, 1(6), 2001, pp. 1101-1121

Abstract

Our increased understanding of the critical role of cytokines in chronic inflammatory/autoimmune diseases has led to the recent development of effective anti-cytokine treatments. In particular, agents blocking the function of TNF-alpha, a cytokine first identified as an endotoxin-inducible mediatorof tumor cell necrosis, are now licensed for the treatment of rheumatoid arthritis (RA) and inflammatory bowel disease. However, TNF-alpha is but onemember of a cytokine network that is responsible for mediating these inflammatory disorders. Therefore, as our understanding of the pathophysiologic role of other members of this inflammatory network increases, other cytokines may similarly be identified as effective targets for treatment. In this article, we will review evidence which suggests that parathyroid hormone-related protein (PTHrP), a peptide which, like TNF-alpha, was first identified because of its effects in the setting of malignancy, may in fact serve animportant non-neoplastic, physiologic function by mediating the inflammatory/autoimmune host response. Data identifying PTHrP as a member of the cytokine network induced in multi-organ inflammation and rheumatoid arthritis will be summarized, initial evidence comparing the therapeutic efficacy of PTHrP- vs. TNF-alpha -blockade in the treatment of endotoxemia will be reviewed, and potential future areas of research, including assessment of the effects of PTHrP blockade in the treatment of RA, will be discussed. (C) 2001Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 19:06:03