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Titolo:
Sex hormones as immunomodulators in health and disease
Autore:
Verthelyi, D;
Indirizzi:
US FDA, Retroviral Immunol Sect, Ctr Biol Evaluat & Res, Bethesda, MD 20892 USA US FDA Bethesda MD USA 20892 r Biol Evaluat & Res, Bethesda, MD 20892 USA
Titolo Testata:
INTERNATIONAL IMMUNOPHARMACOLOGY
fascicolo: 6, volume: 1, anno: 2001,
pagine: 983 - 993
SICI:
1567-5769(200106)1:6<983:SHAIIH>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
SYSTEMIC-LUPUS-ERYTHEMATOSUS; ESTROGEN REPLACEMENT THERAPY; T-CELL CLONES; AUTOIMMUNE-DISEASE; PERIPHERAL-BLOOD; IMMUNE-SYSTEM; MURINE LUPUS; B-CELLS; MENSTRUAL-CYCLE; DISCOID LUPUS;
Keywords:
estrogen; dehydroepiandrosterone sulphate; cytokines; systemic lupus erythematosus;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
90
Recensione:
Indirizzi per estratti:
Indirizzo: Verthelyi, D US FDA, Retroviral Immunol Sect, Ctr Biol Evaluat & Res, Bldg29A,Rm 3 D 2, Bethesda, MD 20892 USA US FDA Bldg 29A,Rm 3 D 2 Bethesda MD USA 20892 , MD 20892 USA
Citazione:
D. Verthelyi, "Sex hormones as immunomodulators in health and disease", INT IMMUNO, 1(6), 2001, pp. 983-993

Abstract

In addition to their effects on sexual differentiation and reproduction, sex hormones influence the immune system. This results in a gender dimorphism in the immune function with females having higher immunoglobulin levels and mounting stronger immune responses following immunization or infection than males. The greater immune responsiveness in females is also evident in their increased susceptibility to autoimmune diseases. However, a clear understanding of the myriad of effects that sex hormones have on the immune system is lacking. Studies in normal mice show that estrogen treatment induces polyclonal B cell activation with increased expression of autoantibodies characteristic of autoimmune diseases. Several mechanisms appear to contribute to the break in tolerance and the increase in plasma cell activity including a reduction of the mass of the bone marrow and the thymus, the emergence of sites of extrameduallary hematopoiesis and altered susceptibility ofB cells to cell death. In addition, sex hormone levels in both humans and experimental models correlated with the activity of their cytokine-secreting cells indicating that sex hormones influence the cytokine milieu and suggesting that altered sex hormonal levels in autoimmune patients contribute to the skewed cytokine milieu characteristic of systemic lupus erythematosus(SLE). While sex hormones alone do not cause autoimmune disease, abnormal hormonelevels may provide the stage for other factors (genetic, infectious) to trigger disease. Understanding the physiology of the interaction between sex hormones and immune function and its potential pathological consequences may provide insight into the autoimmune diseases and new directions for theirtreatment. Published by Elsevier Science B.V.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/07/20 alle ore 01:45:13