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Titolo:
Mucosal administration of IL-10 enhances oral tolerance in autoimmune encephalomyelitis and diabetes
Autore:
Slavin, AJ; Maron, R; Weiner, HL;
Indirizzi:
Harvard Univ, Sch Med, Brigham & Womens Hosp, Ctr Neurol Dis, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 sp, Ctr Neurol Dis, Boston, MA 02115 USA
Titolo Testata:
INTERNATIONAL IMMUNOLOGY
fascicolo: 6, volume: 13, anno: 2001,
pagine: 825 - 833
SICI:
0953-8178(200106)13:6<825:MAOIEO>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS; COLLAGEN-INDUCED ARTHRITIS; CD4(+) T-CELLS; MESSENGER-RNA EXPRESSION; MYASTHENIA-GRAVIS EAMG; MYELIN BASIC-PROTEIN; IFN-GAMMA; TGF-BETA; TRANSGENIC MICE; DENDRITIC CELLS;
Keywords:
autoimmunity; IL-10; mucosa; tolerance;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
58
Recensione:
Indirizzi per estratti:
Indirizzo: Weiner, HL Harvard Univ, Sch Med, Brigham & Womens Hosp, Ctr Neurol Dis, 77 Ave LouisPasteur, Boston, MA 02115 USA Harvard Univ 77 Ave Louis Pasteur Boston MA USA 02115 02115 USA
Citazione:
A.J. Slavin et al., "Mucosal administration of IL-10 enhances oral tolerance in autoimmune encephalomyelitis and diabetes", INT IMMUNOL, 13(6), 2001, pp. 825-833

Abstract

IL-10 is an immunoregulatory cytokine that can modulate immune processes, inhibiting the expression of inflammatory T(h)1 type responses as well as affecting antigen-presenting cell function. In addition, IL-10 has been shown to be active at mucosal surfaces, in the present study, we examined the role of IL-10 on orally and nasally induced tolerance. Treatment of(PL/J x SJL)F-1 mice with low-dose oral myelin basic protein (MBP) (0.5 mg) and simultaneous oral IL-10 given 3 times reduced the severity and incidence of experimental autoimmune encephalomyelitis (EAE), whereas administration of oral IL-10 alone or MBP alone given in these doses had no effect, Lymphocytes From mice treated orally with Map and IL-10 proliferated less, and produceddecreased amounts of IFN-gamma and IL-2 and increased amounts of IL-10 andtransforming growth factor-beta upon in vitro stimulation with MBP. Nasal administration of antigen and IL-10 reduced proliferative responses and IFN-gamma production, increased IL-10 production, and enhanced protection fromEAE. In addition, oral IL-10 combined with oral myelin oligodendrocyte glycoprotein (MOG) 35-55 reduced relapses in MOG-induced EAE in the NOD mouse,as well as enhanced the protective effect of oral insulin in the NOD modelof diabetes, These results demonstrate that IL-10 is biologically active at mucosal surfaces and can act synergistically to enhance the tolerogenic effects of mucosally administered antigen.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 18:04:02