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Titolo:
Comparison of gene expression of cytokines mRNA in lungs of rats induced by intratracheal instillation and inhalation of mineral fibers
Autore:
Morimoto, Y; Tsuda, T; Yamato, H; Oyabu, T; Higashi, T; Tanaka, I; Kasai, T; Ishimatsu, S; Hori, H; Kido, M;
Indirizzi:
Univ Occupat & Environm Hlth, Inst Ind & Ecol Sci, Dept Occupat Pneumol, Kitakyushu, Fukuoka 8078555, Japan Univ Occupat & Environm Hlth Kitakyushu Fukuoka Japan 8078555 8555, Japan Univ Occupat & Environm Hlth, Dept Pathol, Kitakyushu, Fukuoka 8078555, Japan Univ Occupat & Environm Hlth Kitakyushu Fukuoka Japan 8078555 8555, Japan Univ Occupat & Environm Hlth, Sch Hlth Sci, Kitakyushu, Fukuoka 8078555, Japan Univ Occupat & Environm Hlth Kitakyushu Fukuoka Japan 8078555 8555, Japan Univ Occupat & Environm Hlth, Dept Resp Dis, Kitakyushu, Fukuoka 8078555, Japan Univ Occupat & Environm Hlth Kitakyushu Fukuoka Japan 8078555 8555, Japan
Titolo Testata:
INHALATION TOXICOLOGY
fascicolo: 7, volume: 13, anno: 2001,
pagine: 589 - 601
SICI:
0895-8378(200107)13:7<589:COGEOC>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; INDUCED PULMONARY FIBROSIS; ASBESTOS EXPOSURE; MESSENGER-RNA; ALVEOLAR MACROPHAGES; RESPIRATORY-TRACT; FISCHER-344 RATS; CIGARETTE-SMOKE; FACTOR-ALPHA; TOXICITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Morimoto, Y Univ Occupat & Environm Hlth, Inst Ind & Ecol Sci, Dept Occupat Pneumol, 1-1 Iseigaoka, Kitakyushu, Fukuoka 8078555, Japan Univ Occupat &Environm Hlth 1-1 Iseigaoka Kitakyushu Fukuoka Japan 8078555
Citazione:
Y. Morimoto et al., "Comparison of gene expression of cytokines mRNA in lungs of rats induced by intratracheal instillation and inhalation of mineral fibers", INHAL TOXIC, 13(7), 2001, pp. 589-601

Abstract

To investigate whether the results of intratracheal instillation studies on mineral fibers reflect the findings obtained by long-term inhalation dataon mineral fibers, we have examined gene expression of cytokines and pathological features in lungs induced by intratracheal instillation and inhalation of mineral fibers. Male Wistar rats were given a single intratracheal instillation of 2 mg alumina silicate refractory fiber (RF1) or potassium octatitanate whisker ( PT1), and were sacrificed 4 wk after the fiber instillation. Longterm inhalation studies were also performed. In these, animals were exposed to fiber aerosol of RF1 or PT1 for 5 days/wk for 1 yr, and sacrificed after 1 yr of inhalation. Expression of tumor necrosis factor-alpha (TNF-alpha), interleukin-6 ( IL-6), and transforming growth factor-beta1 ( TGF-beta1) from lungs was observed by reverse-transcription polymerase chain reaction (RT-PCR). The expression of TNF-alpha, IL-6, and TGF-beta1 mRNA in PT1-exposed lung was significantly higher than for those exposed to RF1 in both intratracheal instillation and inhalation studies. Pathological findings revealed that mild pulmonary fibrosis was seen in the lungs after intratracheal instillation and inhalation of PT1 but not RF1. Similarities were observed not only in gene expression of cytokines but in pathological features between both studies. These data suggested that the results of intratracheal instillation reflect the findings obtained from long-term inhalation data.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/07/20 alle ore 20:55:02