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Titolo:
Lack of correlation between Mbo I restriction fragment length polymorphismof renin gene and essential hypertension in Japanese
Autore:
Fu, YX; Katsuya, T; Asai, T; Fukuda, M; Inamoto, N; Iwashima, Y; Sugimoto, K; Rakugi, H; Higaki, J; Ogihara, T;
Indirizzi:
Osaka Univ, Grad Sch, Sch Med, Dept Geriatr Med, Suita, Osaka 5650871, Japan Osaka Univ Suita Osaka Japan 5650871 atr Med, Suita, Osaka 5650871, Japan
Titolo Testata:
Hypertension research
fascicolo: 3, volume: 24, anno: 2001,
pagine: 295 - 298
Fonte:
ISI
Lingua:
ENG
Soggetto:
MOUSE REN-2 GENE; BLOOD-PRESSURE; RAT RENIN; DAHL RATS; ASSOCIATION; LINKAGE; ANGIOTENSINOGEN; COSEGREGATION; ALLELES; LOCUS;
Keywords:
hypertension; renin gene; Mbo I-RFLP; case-control study;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Ogihara, T Osaka Univ, Grad Sch, Sch Med, Dept Geriatr Med, 2-2 Yamadaoka,B6, Suita, Osaka 5650871, Japan Osaka Univ 2-2 Yamadaoka,B6 Suita Osaka Japan 5650871 71, Japan
Citazione:
Y.X. Fu et al., "Lack of correlation between Mbo I restriction fragment length polymorphismof renin gene and essential hypertension in Japanese", HYPERTENS R, 24(3), 2001, pp. 295-298

Abstract

Predisposition to essential hypertension Is associated with gene polymorphisms of the renin angiotensin system (RAS), Gene polymorphisms of the angiotensinogen and angiotensin converting enzyme genes are known to be risk factors for hypertension, while few studies concerning the renin gene polymorphism have been published. In the present investigation, we carried out a case control study using a Japanese population to examine the genetic influence of the renin gene on the predisposition to hypertension. Patients (n=235) recruited from outpatients at Osaka University Hospital and diagnosed with essential hypertension or receiving long-term antihypertensive medicationparticipated in the study. Normotensive control subjects (n=510) without ahistory of hypertension and without diabetes mellitus were recruited from the same population, and were sex-matched with experimental subjects. A polymorphism in intron 9 of the human renin gene was determined as the Mbo I restriction fragment length polymorphism(Mbo I-RFLP), There was no significant association between Mbo I-RFLP of the renin gene and predisposition to essential hypertension In Japanese (p >0.05, chi (2)=2.1). These results suggest that the Mbo I (+) allele of the renin gene does not increase the riskfor hypertension in Japanese.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 00:41:30